Zhong HJ, Sun HH, Xue LF, McGowan EM, Chen Y. Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis. World J Gastroenterol 2019; 25(3): 378-387 [PMID: 30686905 DOI: 10.3748/wjg.v25.i3.378]
Corresponding Author of This Article
Yu Chen, MD, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19, Nonglinxia Road, Guangzhou 510000, Guangdong Province, China. yuchen@gdpu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
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World J Gastroenterol. Jan 21, 2019; 25(3): 378-387 Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.378
Table 1 Characteristics of patients with cirrhosis
Wilson disease-associated cirrhosis (n = 60)
Hepatitis B-associated cirrhosis (n = 56)
P value
Age (yr)
22.00 (16.25-29.75)
52.00 (45.25-62.00)
< 0.001
Male gender
27 (45.00)
46 (82.14)
< 0.001
Disease duration (years)
3.00 (1.13-7.00)
17.50 (3.25-38.25)
< 0.001
Diabetes
1 (1.67)
11 (19.64)
0.001
Hypertension
0 (0)
13 (23.21)
< 0.001
Alcohol drinking
0 (0)
12 (21.42)
< 0.001
Smoking
2 (3.33)
13 (23.21)
0.001
TC (mmol/L)
4.22 (3.67-4.67) (n = 39)
4.10 (2.71-4.67) (n = 39)
0.327
TG (mmol/L)
0.94 (0.70-1.37) (n = 39)
0.99 (0.65-1.60) (n = 39)
0.853
HDL (mmol/L)
1.40 ± 0.30 (n = 39)
1.16 ± 0.32 (n = 39)
0.786
LDL (mmol/L)
2.17 ± 0.61 (n = 39)
2.28 ± 0.91 (n = 39)
0.014
Table 2 Relationship between cirrhotic etiology and liver fibrosis markers
Wilson disease-associated cirrhosis (n = 60)
Hepatitis B-associated cirrhosis (n = 53)
P value
Type IV collagen (ng/mL)
61.55 (52.18-72.11)
79.48 (63.16-107.56)
< 0.001
PIIINP (μg/mL)
79.92(54.68-122.65)
109.16 (70.24-155.30)
0.019
Laminin (ng/mL)
104.09 (92.80-118.21)
96.27 (70.08-116.02)
0.013
Hyaluronic acid (ng/mL)
75.12 (39.27-131.98)
193.16 (74.77-625.90)
< 0.001
Table 3 Relationship between cirrhotic etiology and liver function indices
Wilson disease-associated cirrhosis (n = 60)
Hepatitis B-associated cirrhosis (n = 56)
P value
ALT (U/L)
23.00 (17.00-34.75)
33.50 (19.33-81.25)
0.002
AST (U/L)
25.00 (19.00-40.00)
41.50 (27.25-96.50)
< 0.001
Albumin (g/L)
40.00 (37.00-43.00)
33.00 (29.25-39.75)
< 0.001
PT (s)
14.05 (13.43-14.78)
15.50 (13.93-18.18)
0.003
Bilirubin (μmol/L)
12.40 (8.55-18.38)
21.70 (12.73-41.08)
< 0.001
Hepatic encephalopathy
0 (0)
3 (5.36)
0.109
Child-Pugh classification
< 0.001
A
54 (90.00)
24 (42.86)
B
4 (6.67)
24 (42.86)
C
2 (3.33)
8 (14.29)
Table 4 Logistic regression analysis of Child-Pugh classification in patients with Wilson disease-associated cirrhosis vs patients with hepatitis B-associated cirrhosis
OR
95%CI
P value
Child-Pugh classification
A
Ref.
-
-
B
0.046
0.006-0.387
0.005
C
0.164
0.013-2.063
0.162
Table 5 Relationship between cirrhotic etiology and features of portal hypertension
Wilson disease-associated cirrhosis (n = 60)
Hepatitis B-associated cirrhosis (n = 56)
P value
Portal vein diameter (mm)
10.00 (8.00-10.00)
14.00 (12.00-16.00)
< 0.001
Ascites
2 (3.33)
24 (42.86)
< 0.001
Splenomegaly/splenectomy
53 (88.33)
42 (75.00)
0.062
Table 6 Logistic regression analysis of risk of hematocytopenia due to splenomegaly
OR
95%CI
P value
Leucopenia
4.41
1.29-15.12
0.018
Erythropenia
-
-
-
Thrombocytopenia
23.08
2.86-186.11
0.003
Citation: Zhong HJ, Sun HH, Xue LF, McGowan EM, Chen Y. Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis. World J Gastroenterol 2019; 25(3): 378-387