Observational Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Jan 21, 2019; 25(3): 378-387
Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.378
Table 1 Characteristics of patients with cirrhosis
Wilson disease-associated cirrhosis (n = 60)Hepatitis B-associated cirrhosis (n = 56)P value
Age (yr)22.00 (16.25-29.75)52.00 (45.25-62.00)< 0.001
Male gender27 (45.00)46 (82.14)< 0.001
Disease duration (years)3.00 (1.13-7.00)17.50 (3.25-38.25)< 0.001
Diabetes1 (1.67)11 (19.64)0.001
Hypertension0 (0)13 (23.21)< 0.001
Alcohol drinking0 (0)12 (21.42)< 0.001
Smoking2 (3.33)13 (23.21)0.001
TC (mmol/L)4.22 (3.67-4.67) (n = 39)4.10 (2.71-4.67) (n = 39)0.327
TG (mmol/L)0.94 (0.70-1.37) (n = 39)0.99 (0.65-1.60) (n = 39)0.853
HDL (mmol/L)1.40 ± 0.30 (n = 39)1.16 ± 0.32 (n = 39)0.786
LDL (mmol/L)2.17 ± 0.61 (n = 39)2.28 ± 0.91 (n = 39)0.014
Table 2 Relationship between cirrhotic etiology and liver fibrosis markers
Wilson disease-associated cirrhosis (n = 60)Hepatitis B-associated cirrhosis (n = 53)P value
Type IV collagen (ng/mL)61.55 (52.18-72.11)79.48 (63.16-107.56)< 0.001
PIIINP (μg/mL)79.92(54.68-122.65)109.16 (70.24-155.30)0.019
Laminin (ng/mL)104.09 (92.80-118.21)96.27 (70.08-116.02)0.013
Hyaluronic acid (ng/mL)75.12 (39.27-131.98)193.16 (74.77-625.90)< 0.001
Table 3 Relationship between cirrhotic etiology and liver function indices
Wilson disease-associated cirrhosis (n = 60)Hepatitis B-associated cirrhosis (n = 56)P value
ALT (U/L)23.00 (17.00-34.75)33.50 (19.33-81.25)0.002
AST (U/L)25.00 (19.00-40.00)41.50 (27.25-96.50)< 0.001
Albumin (g/L)40.00 (37.00-43.00)33.00 (29.25-39.75)< 0.001
PT (s)14.05 (13.43-14.78)15.50 (13.93-18.18)0.003
Bilirubin (μmol/L)12.40 (8.55-18.38)21.70 (12.73-41.08)< 0.001
Hepatic encephalopathy0 (0)3 (5.36)0.109
Child-Pugh classification< 0.001
A54 (90.00)24 (42.86)
B4 (6.67)24 (42.86)
C2 (3.33)8 (14.29)
Table 4 Logistic regression analysis of Child-Pugh classification in patients with Wilson disease-associated cirrhosis vs patients with hepatitis B-associated cirrhosis
OR95%CIP value
Child-Pugh classification
ARef.--
B0.0460.006-0.3870.005
C0.1640.013-2.0630.162
Table 5 Relationship between cirrhotic etiology and features of portal hypertension
Wilson disease-associated cirrhosis (n = 60)Hepatitis B-associated cirrhosis (n = 56)P value
Portal vein diameter (mm)10.00 (8.00-10.00)14.00 (12.00-16.00)< 0.001
Ascites2 (3.33)24 (42.86)< 0.001
Splenomegaly/splenectomy53 (88.33)42 (75.00)0.062
Table 6 Logistic regression analysis of risk of hematocytopenia due to splenomegaly
OR95%CIP value
Leucopenia4.411.29-15.120.018
Erythropenia---
Thrombocytopenia23.082.86-186.110.003