Copyright
©The Author(s) 2019.
World J Gastroenterol. Jun 14, 2019; 25(22): 2763-2775
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2763
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2763
Tissue samples | Serum samples | Healthy controls | |
(n = 25) | |||
Gender | |||
Male | 15 | 57 | 26 |
Female | 10 | 37 | 14 |
Age | |||
Mean ± SD | 60 ± 7 | 59 ± 7 | 59 ± 8 |
Median (range) | 61 (45-72) | 60 (40-74) | 60 (41-74) |
Tumor size (cm) | |||
<5 | 19 | 59 | |
≥5 | 6 | 35 | |
TNM stage | |||
I | 13 | 18 | |
II | 9 | 21 | |
III | 3 | 42 | |
IV | 0 | 13 | |
Differentiation | |||
Well and moderate | 13 | 50 | |
Poor | 12 | 44 | |
Invasion depth | |||
T1 | 3 | 9 | |
T2 | 7 | 32 | |
T3 | 12 | 35 | |
T4 | 3 | 18 | |
Lymph node metastasis | |||
Positive | 18 | 50 | |
Negative | 7 | 44 |
Clinical feature | Cases | Serum HOXA11-AS | P-value |
Gender | 0.824 | ||
Male | 57 | 0.345 ± 0.104 | |
Female | 37 | 0.349 ± 0.091 | |
Age (yr) | 0.304 | ||
<60 | 38 | 0.337 ± 0.111 | |
≥60 | 56 | 0.355 ± 0.089 | |
Tumor size (cm) | 0.001 | ||
<5 | 59 | 0.320 ± 0.094 | |
≥5 | 35 | 0.391 ± 0.092 | |
TNM stage | 0.001 | ||
I and II | 39 | 0.250 ± 0.073 | |
III and IV | 55 | 0.415 ± 0.040 | |
Differentiation | 0.934 | ||
Well and moderate | 50 | 0.346 ± 0.112 | |
Poor | 44 | 0.347 ± 0.084 | |
Invasion depth | 0.867 | ||
T1 and T2 | 41 | 0.348 ± 0.100 | |
T3 and T4 | 53 | 0.345 ± 0.099 | |
Lymph node metastasis | 0.011 | ||
Positive | 50 | 0.377 ± 0.088 | |
Negative | 44 | 0.312 ± 0.100 |
Variable | Univariate analysis | Multivariate analysis | ||||
HR | 95%CI | P-value | HR | 95%CI | P-value | |
Gender (Male vs Female) | 1.310 | 0.749-2.291 | 0.344 | - - - | - - - | - - - |
Age (yr) (<60 vs ≥60) | 0.987 | 0.560-1.739 | 0.963 | - - - | - - - | - - - |
Tumor size (cm) (<5 vs ≥5) | 0.527 | 0.301-0.924 | 0.025 | 0.816 | 0.442-1.508 | 0.516 |
TNM stage (I + II vs III + IV) | 0.195 | 0.092-0.417 | 0.001 | 0.437 | 0.125-1.522 | 0.193 |
Differentiation (Well and moderate vs Poor) | 0.923 | 0.529-1.61 | 0.779 | - - - | - - - | - - - |
Invasion depth (T1 + T2 vs T3 vs T4) | 1.050 | 0.601-1.836 | 0.863 | - - - | - - - | - - - |
Lymph node metastasis (Positive vs Negative) | 0.667 | 0.379-1.176 | 0.162 | - - - | - - - | - - - |
Serum HOXA11-AS (High vs Low) | 0.201 | 0.104-0.385 | 0.001 | 0.338 | 0.115-0.989 | 0.048 |
- Citation: Liu Y, Zhang YM, Ma FB, Pan SR, Liu BZ. Long noncoding RNA HOXA11-AS promotes gastric cancer cell proliferation and invasion via SRSF1 and functions as a biomarker in gastric cancer. World J Gastroenterol 2019; 25(22): 2763-2775
- URL: https://www.wjgnet.com/1007-9327/full/v25/i22/2763.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i22.2763