Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2019; 25(22): 2763-2775
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2763
Long noncoding RNA HOXA11-AS promotes gastric cancer cell proliferation and invasion via SRSF1 and functions as a biomarker in gastric cancer
Yun Liu, Yu-Mei Zhang, Feng-Bo Ma, Su-Rong Pan, Bao-Zhen Liu
Yun Liu, Department of Operating Room, Binzhou People's Hospital, Binzhou 256610, Shandong Province, China
Yu-Mei Zhang, Department of Return Visit, Binzhou People's Hospital, Binzhou 256610, Shandong Province, China
Feng-Bo Ma, Su-Rong Pan, Bao-Zhen Liu, Department of Gastroenterology, Binzhou People's Hospital, Binzhou 256610, Shandong Province, China
Author contributions: Liu BZ designed the research; Liu Y, Zhang YM, Ma FB, and Pan SR performed the research; Liu Y analyzed the data; Liu Y and Liu BZ wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board Committee of Binzhou People's Hospital.
Conflict-of-interest statement: We declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bao-Zhen Liu, PhD, Doctor, Department of Gastroenterology, Binzhou People's Hospital, Binzhou 256610, Shandong Province, China. zhebaonnt3411@163.com
Telephone: +86-543-3282396
Received: March 28, 2019
Peer-review started: March 28, 2019
First decision: April 11, 2019
Revised: April 15, 2019
Accepted: May 3, 2019
Article in press: May 3, 2019
Published online: June 14, 2019
Processing time: 79 Days and 0.6 Hours
Core Tip

Core tip: The long noncoding RNA (lncRNA) HOXA11-AS is up-regulated in gastric cancer (GC) tissues, cell lines, and serum samples. In GC patients, increased serum HOXA11-AS levels were positively related with tumor size, TNM stage, and lymph node metastasis. HOXA11-AS functions as a diagnostic and prognostic biomarker in GC, and promotes GC cell proliferation and invasion. SRSF1 may be the target regulated by HOXA11-AS in gastric cells.