Chronic functional constipation is strongly linked to vitamin D deficiency

doi:10.3748/wjg.v25.i14.1729

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 14

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (17618)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

918

WORD

255

HTML

11316

Figures (1-2)

533

Tables (1-2)

516

Sum=13538

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1128

Download

2952

Sum=4080

Apr 14, 2019 (publication date) through Nov 11, 2025

Times Cited of This Article

Times Cited (45)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Case Control Study

World J Gastroenterol. Apr 14, 2019; 25(14): 1729-1740
Published online Apr 14, 2019. doi: 10.3748/wjg.v25.i14.1729

Table 1 Characteristics of patients with functional chronic constipation with intestinal motility disorders and of controls

Variables	Intestinal motility disorders (n = 86)	Controls (n = 86)
Age, mean ± SD , yr	49.9 (17.4)	50 (17.1)
Sex, n (%)
Male	13 (15.1)	13 (15.1)
Female	73 (84.9)	73 (84.9)
BMI, mean ± SD, kg/m²	23.7 (2.8)	24.6 (3.4)
Education, n (%)
Primary	5 (5.8)	5 (5.8)
Intermediate	33 (38.4)^a	14 (16.3)^a
High school	38 (44.2)	37 (43)
Bachelor degree	10 (11.6)^a	28 (32.6)^a
No data	0	2 (2.3)
Marital status
Single	30 (34.9)	22 (25.6)
Married	53 (61.6)	58 (67.4)
Widower	3 (3.5)	4 (4.7)
Divorced	0	1 (1.2)
No data	0	1 (1.2)
Symptoms
Constipation	78 (90.1)^a	3 (3.5)^a
Abdominal pain	73 (84.9)^a	2 (2.3)^a
Swelling	79 (91.9)^a	14 (16)^a
IBS-QOL (total score)	108.4 (23.7)^a	39.8 (7.7)^a
Dysphoria	24.1 (7.7)^a	8.7 (1.5)^a
Interference	15.9 (5.5)^a	8 (1.6)^a
Body image	15 (2.1)^a	4.8 (1.4)^a
Anxiety health	13.5 (1.8)^a	3.7 (1.4)^a
Food avoidance	13.6 (1.6)^a	3.7 (1.4)^a
Social reaction	10.8 (3.2)^a	5 (1.1)^a
Interpersonal relationships	6.3 (3.3)^a	3.3 (0.6)^a
Sexuality	4.6 (2.2)^a	2 (0.1)^a
HADS-14 A	14.6 (4.3)^a	2.4 (1.8)^a
HADS-14 D	14.6 (3.1)^a	4.5 (2.6)^a
SF12-PCS	37.3 (9.8)^a	47.2 (7.6)^a
SF12-MCS	29.1 (7.4)^a	56 (7.1)^a
PTH, mean ± SD, 10-70 pg/mL	51.1 (12.1)	-
Vitamin D, mean ± SD, IU/mL	14.6 (7.7)^a	28.4 (8.8)^a

^aP < 0.01 vs controls by t, F or χ². Values are absolute numbers and percentages (in parentheses) or average numbers and standard deviation (in parentheses). BMI: Body mass index; IBS-QOL: Irritable Bowel Syndrome Quality of life; HADS-14 A: Hospital Anxiety and Depression Scale-14 for Anxiety; HADS-14 D: Hospital Anxiety and Depression Scale-14 for Depression; SF12-PCS: Short Form Health Survey12-Physical Component Summary; SF12-MCS: Short Form Health Survey12-Mental Component Summary; PTH: Parathyroid hormone.

Full Size Table

Table 2 Probability of intestinal motility disorder occurrence at the univariate and multivariate analysis

Variable	Univariate analysis		Multivariate analysis
Variable	OR (95%CI)	P value	OR¹(95%CI)	P value
Age, yr	1.0 (0.98-1.01)	0.76	-	-
BMI, kg/m²	0.91 (0.82-1.0)	0.04	0.98 (0.86-1.11)	0.72
Vitamin D, IU/mL	0.82 (0.78-0.87)	< 0.001	0.83 (0.78-0.87)	< 0.001

¹Adjusted for all variables in the multivariate model. BMI: Body mass index. OR: Odds ratio; CI: Confidence interval.

Full Size Table

Citation: Panarese A, Pesce F, Porcelli P, Riezzo G, Iacovazzi PA, Leone CM, De Carne M, Rinaldi CM, Shahini E. Chronic functional constipation is strongly linked to vitamin D deficiency. World J Gastroenterol 2019; 25(14): 1729-1740
URL: https://www.wjgnet.com/1007-9327/full/v25/i14/1729.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i14.1729