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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2019; 25(14): 1729-1740
Published online Apr 14, 2019. doi: 10.3748/wjg.v25.i14.1729
Published online Apr 14, 2019. doi: 10.3748/wjg.v25.i14.1729
Chronic functional constipation is strongly linked to vitamin D deficiency
Alba Panarese, Massimo De Carne, Endrit Shahini, Department of Gastroenterology and Digestive Endoscopy, Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital, Castellana Grotte (Bari) 70013, Italy
Francesco Pesce, Nephrology section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70013, Italy
Piero Porcelli, Department of Psychological, Health, and Territorial Sciences, D'Annunzio University of Chieti-Pescara, Chieti 70013, Italy
Giuseppe Riezzo, Palma Aurelia Iacovazzi, Carla Maria Leone, Department of Clinical Pathology, Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital, Castellana Grotte (Bari) 70013, Italy
Caterina Mammone Rinaldi, Department of Radiology, Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital, Castellana Grotte (Bari) 70013, Italy
Endrit Shahini, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy
Author contributions: Panarese A has conceived the protocol; Shahini E and Panarese A drafted the initial and final manuscript; Panarese A enrolled patients; Panarese A, and Leone CM collected in a database the baseline and on-treatment information; Shahini E, Pesce F and Porcelli P systematically reviewed the data entries for completeness and consistency, checked for completeness of information and performed the statistical analysis; all the authors reviewed and approved the final draft.
Institutional review board statement: National Institute of Gastroenterology “S. De Bellis” Research Hospital (0807/16) and by the Research Ethics Committee of the National Oncological Institute of Bari (CAAE:147/16) (Trial registration number: NCT03096704).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All authors declare no conflict of interest related to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
STROBE statement: The guidelines of the STROBE Statement have been adopted.
Corresponding author: Alba Panarese, MD, Doctor, Department of Gastroenterology and Digestive Endoscopy, Scientific Institute for Digestive Disease "Saverio de Bellis" Hospital, Turi Street n. 27, Castellana Grotte (Bari) 70013, Italy. alba.panarese@irccsdebellis.it
Telephone: +39-3471401487; +39-0804994251 Fax: +39-0804994250
Received: February 16, 2019
Peer-review started: February 18, 2019
First decision: February 26, 2019
Revised: March 11, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: April 14, 2019
Processing time: 55 Days and 19.7 Hours
Peer-review started: February 18, 2019
First decision: February 26, 2019
Revised: March 11, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: April 14, 2019
Processing time: 55 Days and 19.7 Hours
Core Tip
Core tip: Intestinal motility disorders, which are disabling conditions associated with chronic constipation, have been examined in only A few studies. Patients with intestinal motility disorders are frequently affected by vitamin D deficiency, which is strongly associated to anxiety, depression symptoms and to severe impairment of quality of life. These data suggest that vitamin D serum levels should be routinely measured, and its supplementation should be evaluated in patients with intestinal motility disorders.