Copyright
©The Author(s) 2018.
World J Gastroenterol. Apr 21, 2018; 24(15): 1622-1631
Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1622
Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1622
6 h after PH | 12 h after PH | |||||||
AST | ALT | T-Bil | IL-6 | AST | ALT | T-Bil | IL-6 | |
Normal 70%PH | 2343.3 ± 6160.4 | 1828.3 ± 990.4 | 1.43 ± 0.5 | 2036.0 ± 1470.9 | 2976.7 ± 1395.7 | 2053.3 ± 886.2 | 2.0 ± 0.9 | 731.5 ± 483.7 |
NASH 30%PH | 1610.0 ± 3700.6 | 1507.1 ± 563.5 | 0.76 ± 0.2 | 1511.5 ± 284.8 | 1841.3 ± 619.1 | 1522.9 ± 537.9 | 0.9 ± 0.7 | 692.8 ± 211.1 |
NASH 70%PH | 3064.3 ± 1289.8a | 2422.9 ± 1194.8 | 2.57 ± 1.36b | 3026.2 ± 2127.5 | 4067.5 ± 2059.2a | 2403.8 ± 1111.8 | 3.85 ± 0.96b | 987.9 ± 550.7 |
Function | Gene name | Gene abbreviation | Fold-change (> 1.4) | P value (< 0.05) |
Regulate the cellular concentrations of cyclic nucleotides | Phosphodiesterase 4B, cAMP-specific | PDE4B | 2.102691211 | 0.0063 |
Growth arrest | Growth arrest and DNA-damage-inducible, alpha | GADD45A | 1.672778704 | 0.013 |
Signal transduction | Coronin 1C | CORO1C | 1.489851976 | 0.031 |
Stimulates expression of cytokines, including IL6, MIF and VEGFA | Hypoxia inducible lipid droplet associated | HILPDA | 1.481465541 | 0.011 |
EGF-like growth factor | Heparin binding EGF-like growth factor | HBEGF | 1.432049736 | 0.043 |
Cell-cell junctions | Membrane associated guanylate kinase, WW And PDZ domain containing 1 | MAGI1 | 1.430522907 | 0.0222 |
Innate immune system | Ankyrin repeat and SOCS box containing 13 | ASB13 | 0.515175325 | 0.0042 |
Apoptosis and autophagy | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | TIAL1 | 0.609948905 | 0.027 |
Gene expression | Nucleic acid binding protein 1 | NABP1 | 0.6558797325 | 0.042 |
Cell cycle | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | SKP2 | 0.6588204077 | 0.044 |
Mitochondrial metabolism | Translocase of inner mitochondrial membrane 9 homolog (yeast) | TIMM9 | 0.6598542503 | 0.042 |
Cytokine signaling in immune system | B-cell CLL/lymphoma 6 | BCL6 | 0.6760241074 | 0.0097 |
Cell cycle | Mutated in colorectal cancers | MCC | 0.6761191711 | 0.0076 |
Gene expression | Zinc finger protein 519 | ZNF519 | 0.6864230003 | 0.028 |
Gene expression | RNA binding motif protein, X-linked | RBMX | 0.6983542235 | 0.012 |
- Citation: Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N. Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis. World J Gastroenterol 2018; 24(15): 1622-1631
- URL: https://www.wjgnet.com/1007-9327/full/v24/i15/1622.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i15.1622