Basic Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Apr 21, 2018; 24(15): 1622-1631
Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1622
Table 1 Serum parameters of normal liver and nonalcoholic steatohepatitis groups after partial hepatectomy
6 h after PH
12 h after PH
ASTALTT-BilIL-6ASTALTT-BilIL-6
Normal 70%PH2343.3 ± 6160.41828.3 ± 990.41.43 ± 0.52036.0 ± 1470.92976.7 ± 1395.72053.3 ± 886.22.0 ± 0.9731.5 ± 483.7
NASH 30%PH1610.0 ± 3700.61507.1 ± 563.50.76 ± 0.21511.5 ± 284.81841.3 ± 619.11522.9 ± 537.90.9 ± 0.7692.8 ± 211.1
NASH 70%PH3064.3 ± 1289.8a2422.9 ± 1194.82.57 ± 1.36b3026.2 ± 2127.54067.5 ± 2059.2a2403.8 ± 1111.83.85 ± 0.96b987.9 ± 550.7
Table 2 Gene expression microarray
FunctionGene nameGene abbreviationFold-change (> 1.4)P value (< 0.05)
Regulate the cellular concentrations of cyclic nucleotidesPhosphodiesterase 4B, cAMP-specificPDE4B2.1026912110.0063
Growth arrestGrowth arrest and DNA-damage-inducible, alphaGADD45A1.6727787040.013
Signal transductionCoronin 1CCORO1C1.4898519760.031
Stimulates expression of cytokines, including IL6, MIF and VEGFAHypoxia inducible lipid droplet associatedHILPDA1.4814655410.011
EGF-like growth factorHeparin binding EGF-like growth factorHBEGF1.4320497360.043
Cell-cell junctionsMembrane associated guanylate kinase, WW And PDZ domain containing 1MAGI11.4305229070.0222
Innate immune systemAnkyrin repeat and SOCS box containing 13ASB130.5151753250.0042
Apoptosis and autophagyTIA1 cytotoxic granule-associated RNA binding protein-like 1TIAL10.6099489050.027
Gene expressionNucleic acid binding protein 1NABP10.65587973250.042
Cell cycleS-phase kinase-associated protein 2, E3 ubiquitin protein ligaseSKP20.65882040770.044
Mitochondrial metabolismTranslocase of inner mitochondrial membrane 9 homolog (yeast)TIMM90.65985425030.042
Cytokine signaling in immune systemB-cell CLL/lymphoma 6BCL60.67602410740.0097
Cell cycleMutated in colorectal cancersMCC0.67611917110.0076
Gene expressionZinc finger protein 519ZNF5190.68642300030.028
Gene expressionRNA binding motif protein, X-linkedRBMX0.69835422350.012