Review
Copyright ©The Author(s) 2018.
World J Gastroenterol. Apr 21, 2018; 24(15): 1591-1600
Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1591
Table 1 Hemodialysis treatment duration and Helicobacter pylori infection status in hemodialysis patients[27], %
< 1 yr1-3 yr3-10 yr> 10 yrP value
H. pylori infection rate23.8 (15/63)16.7 (18/108)15.0 (34/226)7.8 (8/13)0.043
Rate of H. pylori negatives55.5 (35/63)62.0 (67/108)68.1 (154/226)68.9 (71/103)> 0.05
Table 2 Helicobacter pylori eradication therapy for chronic renal failure patients
YearAuthorCountrynRegimenTreatment periodEradication rate (%)Analytic methods
1997Tamura et al[61]Japan14LPZ (30) oid/ 8 wk, AMPC (500) oid/ 3 wk, plaunotol (80) tid/ 24 wk21 d78.6RUT, Culture, Histology
1998Munos de Bustillo E et al[30]Spain23OPZ (20) bid, AMPC (500) tid14 d60.8UBT
23plus OPZ (20) bid, CAM (500) bid14 d82.6
1998Tokushima et al[62]Japan17LPZ (30) oid/ 8 wk, AMPC (500)21 d76.5RUT, Culture, Histology
10LPZ (30) oid, AMPC (250), MNZ (250) bid/7 d90
1999Araki et al[63]Japan17OPZ (20) oid/ 8 wk, AMPC (250) oid, CAM (200) oid/ 3 wk, polaprizinc (0.5) bid/ 24 wk21 d88.2IgG, Histology
1999Gur et al[11]Turkey25FAM (40) oid, CAM (500) bid, MNZ (250) bid15 d80Histology, RUT
2001Wang et al[64]China38OPZ (20), AMPC (1000), CAM (500) bid7 d86.8Stool
2002Mak et al[91]China21 (CRF)OPZ (20), AMPC (1000), CAM (500) bid7 d90.5RUT
2002Tsukada et al[65]Japan39OPZ (30) bid, AMPC (500) tid, CAM (400) bid7 d82.1UBT
2003Mak et al[92]China25 (CRF)OPZ (20) or LPZ (30), AMPC (1000), CAM (500) bid7 d96Histology
2003Sheu et al[67]China38 (CRF)LPZ (30), AMPC (750), CAM (500) bid7 d76.3
40 (CRF)LPZ (30), CAM (500), MNZ (500) bid7 d92.5Stool
2004Sezer et al[4]Turkey17OPZ (20), AMPC (1000), CAM (500) bid/14 d94.1Endoscopy
2007Tseng et al[93]China34 (CRF)ESO (40) or OPZ (20) bid, AMPC (1000) bid, CAM (500) bid7 d94.1UBT
2007Itatsu et al[69]Japan11LPZ (60), AMPC (750), CAM (400)7 d72.7RUT
9LPZ (60), CAM (400)7 d33.3
2010Change et al[70]Korea12OPZ (20), AMPC (250), CAM (250), bid7 d83.4RUT, Histology
2010Jalalzadeh et al[94], Falaknazi et al[95]Iran37OPZ (20), AMPC (1000), CAM (250), bid14 d81.1IgG, UBT, Stool
2012Seyyedmajidi et al[96], Jalalzadeh et al[97,98]Iran17OPZ (20), AMPC (500), CAM (250), bid14 d82.4UBT, Stool
Vafaeimanesh et al[99]
20OPZ (40), AMPC (500), azithromycin (250), bid14 d80
2014Makhlough et al[100]Iran21PPZ (40), AMPC (500), CAM (250), bid14 d66.7RUT, Histology
24Sequential therapy (PPT [40] 10 d, AMPC (500) bid, 5 d and CAM (250), tinidazole (500), bid, 5 d10 d84
2016Makhlough et al[101]Iran20PPZ (40), AMPC (500), CAM (500), bid14 d70RUT, Stool
20Hybrid regimen PPZ (40), AMPC (500), bid, 7 d + PPZ (40), AMPC (500), CAM (500), tinidazole (500), bid, 7 d14 d100
2018Sahara et al[55]Japan18ESO (20), AMPC (750), CAM (200) bid7 d77.8IgG
19ESO (20), AMPC (250), CAM (200) bid7 d84.2
Table 3 Clinical characteristics in hemodialysis patients between patients with and without gastric mucosal atrophy[19]
Atrophy (-)Atrophy (+)P-value
N (Male/Female)28 (17/11)50 (33/17)-
Age67.7 ± 12.371.6 ± 11.00.155
Dialysis periods (yr)7.5 (2.4-16.8)7.7 (3.1-12.7)0.681
Acyl-ghrelin38.0 (23.5-57.0)18.0 (12.0-26.3)< 0.001
Desacyl-ghrelin303 (248-533)200 (137-277)< 0.001
BMI (kg/m2)19.8 ± 3.219.6 ± 2.80.773
Albumin (g/dL)3.5 ± 0.33.4 ± 0.40.273
Total cholesterol (mg/dL)166 ± 37154 ± 360.165
Cholinesterase (U/L)245 ± 111219 ± 68.70.205
Intact PTH (pg/mL)351 ± 294247 ± 1920.062
Ferritin (ng/mL)128 ± 118128 ± 2210.989
PG I (ng/mL)416.2 (314.2-783.7)196.0 (73.8-358.8)< 0.001
PG II (ng/mL)42.3 (31.6-60.0)28.4 (16.8-45.7)0.003
PG I/II ratio10.89 (9.11-13.38)7.31 (4.17-11.08)0.001
nPCR (g/kg/d)0.94 ± 0.140.85 ± 0.160.022
Table 4 Plasma acyl-ghrelin and desacyl-ghrelin levels according to Helicobacter pylori status in hemodialysis patients[18]
Non-infection (n = 29)Past-infection (n = 27)Present infection (n = 17)
Plasma acyl-ghrelin (fmol/mL)39.4 ± 23.023.4 ± 19.9a24.6 ± 17.5a
Plasma desacyl-ghrelin (fmol/mL)353.2 ± 190.2242.1 ± 139.6a236.3 ± 143.6a