Prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample single-center retrospective study

Table 1 Demographic data of the 469 patients with gastric cancer, n (%)

Characteristics	CEA-Low group(n = 421)	CEA-High group( n = 48)	P value
Age (yr), mean ± SD	58.74 ± 10.98, 60 (20-83)	60.4 ± 11.55, 61 (31-78)
Gender
Female	118 (28)	12 (25)	0.657
Male	303 (72)	36 (75)
Male-to-female ratio	2.81:1	3:01
Family history
Positive	8 (1.9)	1 (2.01)	0.930
Negative	413 (98.1)	47 (97.99)
HP infection status
Positive	37 (8.8)	5 (10.4)	0.708
Negative	384 (91.2)	43 (89.6)
BMI (kg/m2)
Less than 18.5	28 (6.65)	4 (8.33)	0.358
18.5-24.99	304 (72.21)	38 (79.17)
More than 25	89 (21.14)	6 (12.5)
Differentiation degree
Well	226 (53.7)	22 (45.8)	0.302
Poor	195 (46.3)	26 (54.2)
Location
Upper	113 (26.8)	16 (33.33)	0.779
Middle	129 (30.64)	10 (20.83)
Lower	168 (39.9)	21 (43.75)
Mixed	11 (2.61)	1 (2.08)
Lauren classification
Intestinal type	105 (24.94)	10 (20.83)	0.668
Diffuse type	270 (64.13)	31 (64.59)
Mixed type	46 (10.93)	7 (14.58)
T category
T1a	68 (16.2)	4 (8.3)	0.033a
T1b	78 (18.5)	5 (10.4)
T2	89 (21.1)	13 (27.1)
T3	65 (15.4)	14 (29.2)
T4a	116 (27.6)	10 (20.8)
T4b	5 (1.2)	2 (4.2)
T1	146 (34.68)	9 (18.75)	0.026a
T2-4b	275 (65.32)	39 (81.25)
Nerve invasion
Positive	70 (16.6)	11 (22.92)	0.275
Negative	351 (83.4)	37 (77.08)
Vessel carcinoma embolus
Positive	72 (17.1)	15 (31.35)	0.017a
Negative	349 (82.9)	33 (68.75)

^aP < 0.05. HP: Helicobacter pylori; BMI: Body mass index; CEA: Carcinoembryonic antigen.

Table 2 Multivariate analysis for stage pTxN0M0 gastric cancer patients with D2 resection

	Univariate analysis				Multivariate analysis
	P value	Exp(B)	95%CI used for Exp (B)		P value	Exp (B)	95%CI used for Exp (B)
			Lower	Upper			Lower	Upper
Family history	0.912	0.923	0.765	1.311	0.069	1.017	0.72	1.896
HP infection status	0.209	0.832	0.781	1.226	0.754	1.088	0.643	1.840
Gender	0.000a	1.716	1.316	2.553	0.590	0.898	0.608	1.327
CEA	0.000a	1.919	1.319	2.352	0.000a	1.924	1.353	2.232
Location	0.245	0.841	0.792	1.234	0.749	1.012	0.861	1.531
Lauren classification	0.241	0.851	0.814	1.091	0.711	1.109	0.891	1.154
T category	0.000a	1.906	1.659	2.271	0.009a	1.714	1.050	2.403
Differentiation degree	0.279	0.932	0.881	1.126	0.784	1.188	0.663	1.640
Nerve invasion	0.971	0.801	0.731	1.145	0.097	0.951	0.7768	1.655
Vessel carcinoma embolus	0.000a	1.764	1.321	2.562	0.983	0.994	0.895	1.660
BMI	0.732	0.812	0.729	1.234	0.356	1.228	0.912	2.229

^aP < 0.05. HP: Helicobacter pylori; BMI: Body mass index; CEA: Carcinoembryonic antigen.

Table 3 Multivariate analysis of overall survival in pTxN0M0 gastric cancer patients

	CEA-Low group (n = 421)				CEA-High group (n = 48)
	P value	Exp(B)	95%CI		P value	Exp(B)	95%CI
			Lower	Upper			Lower	Upper
Family history	0.077	2.978	0.888	3.986	0.512	1.191	0.501	2.019
HP infection status	0.140	1.590	0.858	2.947	0.247	0.522	0.174	1.570
Gender	0.478	0.834	0.504	1.378	0.919	1.036	0.527	2.037
Location	0.482	0.831	0.764	1.124	0.897	1.012	0.752	2.102
Lauren classification	0.831	0.911	0.891	1.103	0.843	1.245	0.984	1.435
T category	0.647	0.941	0.725	1.222	0.001a	1.962	1.139	2.629
Differentiation degree	0.879	0.931	0.811	1.176	0.884	1.148	0.673	1.641
Nerves invaded	0.811	1.090	0.539	2.205	0.987	0.993	0.438	2.251
Vessel carcinoma embolus	0.064	0.315	0.093	1.068	0.883	0.889	0.685	2.281
BMI	0.392	0.424	0.851	1.124	0.356	1.228	0.912	2.229