Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother

Table 1 Characteristics of the pediatric patients receiving liver transplantation (n = 26) according to the presence or absence of HLA-DR NIMA-MC n (%)

Factors1	NIMA-MC (+)	NIMA-MC (-)	P value
	(n = 6)	(n = 20)
Age at the time of transplantation in years (range)	6.1 (1-14)	6.7 (0-16)	0.57
Age at the time of transplantation (less than 12 mo)	3 (50.0)	7 (35.0)	0.64
Sex, male: female	4 (66.7): 2 (33.3)	6 (30.0): 14 (70.0)	0.16
Recipient weight, kg (range)	28.9 (10.8-54.5)	27.8 (8.1-56.3)	0.92
Original liver disease			0.65
Biliary atresia	4 (66.7)	9 (45.0)
Others	2 (33.3)	11 (55.0)
ABO identical to that of mother	3 (50.0)	13 (65.0)	> 0.99

¹Continuous data are presented as median values with range. NIMA-MC: Microchimerism (MC) to non-inherited maternal antigen (NIMA).

Table 2 Biopsy-proven cellular rejection rate in pediatric patients receiving liver transplantation with maternal graft (n = 23) according to the presence or absence of pretransplantation HLA-DR NIMA-MC and HLA-DR match status n (%)

NIMA-MC and HLA-DR match status	Biopsy-proven cellular rejection	P valuea
NIMA-MC (-) (n = 10)	5 (50.0)
NIMA-MC (+) (n = 3)	0 (0)	0.23
NIMA-MC (+) or HLA-DR 0 mismatch with mother (n = 11)	2 (18.2)	0.18
NIMA-MC (+) or HLA-DR identity with mother (n = 7)	0 (0)	0.04
Total transplantation with maternal graft (n = 23)	8 (34.8)

^aP value for comparison with NIMA-MC (-) group, by two-tailed Fisher’s exact test. NIMA-MC: Microchimerism (MC) to non-inherited maternal antigen (NIMA).

Table 3 Characteristics of pediatric patients receiving liver transplantation with maternal graft (n = 17) according to the presence or absence of pretransplantation HLA-DR NIMA-MC and HLA-DR match status n (%)

Factors1	NIMA-MC (+) or HLA-DR identity with mother	NIMA-MC (-)	P value
	(n = 7)	(n = 10)
Age at the time of transplantation in years, median (range)	5.6 (0.8-10)	7.3 (0.8-16)	0.42
Age at the time of transplantation (less than 12 mo)	3 (42.9)	4 (40.0)	> 0.99
Sex, male: female	3 (42.9): 4 (57.1)	4 (40.0): 6 (60.0)	> 0.99
Recipient weight, kg, median (range)	27.4 (6.2-54.5)	26.0 (9.6-56.3)	> 0.99
Original liver disease			0.64
Biliary atresia	4 (57.1)	4 (40.0)
Others	3 (42.9)	6 (60.0)
Crossmatch positivity	0 (0)	1 (10.0)	> 0.99
ABO identical to that of mother	7 (100)	7 (70.0)	0.23
PELD score, median (range)	11.2 (-7.7-39)	2.3 (-10.0-14.1)	0.27
The year of LT (before 2007)	2 (28.6)	3 (30.0)	> 0.99
Donor age in years, median (range)	34 (26-39)	38 (33-43)	0.16
Sex match, yes: no	4:3	6:4	0.65
Operation time, median, min, median (range)	443 (300-595)	492 (285-710)	0.46
Graft vs recipient weight ratio, %, median (range)	2.68 (1.62-3.23)	2.15 (1.23-2.96)	0.40
Follow-up duration, mo, median (range)	84 (63-176)	66 (30-114)	0.32
Graft failure	0 (0)	0 (0)	> 0.99
Biopsy-proven cellular rejection	0 (0)	5 (50)	0.04

¹Continuous data are presented as median values with range. NIMA-MC: Microchimerism (MC) to non-inherited maternal antigen (NIMA); LT: Liver transplantation.