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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2017; 23(45): 8017-8026
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8017
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8017
Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother
Nam-Joon Yi, Min-Su Park, Hye Young Ahn, Jeik Byun, Hyeyoung Kim, Suk Kyun Hong, Kyungchul Yoon, Hyo-Sin Kim, Sung-Woo Ahn, Hae Won Lee, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh, Department of Surgery, Seoul National University College of Medicine, Seoul 03080, South Korea
Min-Su Park, Department of Surgery, Kyung Hee University School of Medicine, Seoul 02447, South Korea
Eun Young Song, Myoung Hee Park, Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, South Korea
Myoung Hee Park, Korea Organ Donation Agency Laboratory, Seoul 06052, South Korea
Author contributions: Yi NJ contributed in research design, analysis of clinical data, and writing of the article; Park MS contributed in research design and analysis of the clinical data; Song EY contributed in laboratory experimental design and analysis of the experimental data; Ahn HY, Byun J, Kim H, Hong SK, Yoon K, Kim HS, Ahn SW, Lee HW and Choi Y contributed equally in the collection of the clinical data; Lee KW and Suh KS contributed equally in critical revision of the paper; Park MH contributed in laboratory experimental design, analysis of experimental data, and writing of the article.
Supported by the Korean Society for Transplantation 2012.
Institutional review board statement: The study was reviewed and approved by the Seoul National University Hospital Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment about personal and medical data collection.
Conflict-of-interest statement: The authors have no conflicts of interest related to this study to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Myoung Hee Park, MD, PhD, Korea Organ Donation Agency Laboratory, 6F, 12, Nonhyeon-ro 132-gil, Gangnam-gu, Seoul 06052, South Korea. parkmhee@snu.ac.kr
Telephone: +82-2-5485639 Fax: +82-2-5485631
Received: July 18, 2017
Peer-review started: July 20, 2017
First decision: September 6, 2017
Revised: September 22, 2017
Accepted: October 26, 2017
Article in press: October 26, 2017
Published online: December 7, 2017
Processing time: 138 Days and 21 Hours
Peer-review started: July 20, 2017
First decision: September 6, 2017
Revised: September 22, 2017
Accepted: October 26, 2017
Article in press: October 26, 2017
Published online: December 7, 2017
Processing time: 138 Days and 21 Hours
Core Tip
Core tip: We firstly investigated the rates of pretransplantation microchimerism (MC) to non-inherited maternal antigens (NIMAs) (NIMA-MC) in pediatric liver transplantation (LT) patients and its effect on biopsy-proven cellular rejection (BPCR) in those receiving maternal grafts. NIMA-MC for HLA-DRB1 alleles was successfully evaluated in 26 of the 45 children, and pretransplantation NIMA-MC was detected in 23.1% of the patients. Our study demonstrated that none of the patients with NIMA-MC positivity or HLA-DR identity with the mother developed BPCR. The presence of pretransplantation NIMA-MC or HLA-DR identity with the mother could be associated with BPCR-free survival in pediatric LT recipients from maternal donors.