Different clinical presentations of metachronous pulmonary metastases after resection of pancreatic ductal adenocarcinoma: Retrospective study and review of the literature

Table 1 Prior disease-free survival and overall survival in patients with metachronous metastases

	n	DFS	OS
Non-pulmonary	96	9.48	16.19
Metachronous pulmonary metastases	20	19.58	31.81
Isolated pulmonary	5	35.44	81.36
Pulmonary and other metastases	15	17.26	23.37
Metastatic cohort	117	10.03	16.90
Entire cohort	159		17.59

DFS: Disease-free survival; OS: Overall survival.

Table 2 Previous reports of metachronous pulmonary metastases

Study	IPM	DFS	MPMR	SMT	SMU	OSPMD
Van den Broeck et al[16] RA 1998-2005	15	17.8	nr	nr	nr	nr
1Katz et al[5] nr 1990-2002	50	nr	nr	nr	nr	nr
2Arnaoutakis et al[17] RCCS 2000-2009	31	34	9	51	23	nr
1Thomas et al[18] RA 1992-2010	7	52.4	7	nr	nr	nr
2Wangjam et al[7] RA 1998-2007	28	12.7	nr	nr	nr	8.5
Downs-Canner et al[20] RA 2000-2010	49	14.9	5	44.4	29.9	nr
Yamashita et al[19] RCCS 2003-2012	14	nr	2	70	nr	nr
Kruger et al[21] RA 2002-2015	22	10.5	nr	nr	nr	25.5
Decoster et al[36] RCCS 2007-2013	22	nr	3	nr	nr	nr
Deeb et al[15] Cserie	5		0
Brieau et al[14] CR	2		2
Kotoulas et al[12] CR	1		1
Moon et al[11] CR	1		1
Sanjeevi et al[13] CR	1		1
Kitasato et al[33] CR + national cases	1	156	1+203
Nakajima et al[23] CR + national cases			173
Present study Cserie 2006-2013	5	34	2	12+	nr	12+

^1,2Same institution;

³Mostly same cases. IPM: Isolated pulmonary metastases; DFS: Median of disease free survival; MPMR: Resected metachronous pulmonary metastases; SMT: Median survival of MPM treated; SMU: Median survival of MPM untreated; OSPMD: OS after diagnose of MPM; RA: Retrospective analysis; RCCD: Retrospective case control study; Cserie: Case serie; CR: Case report.