Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer

Table 1 Patient characteristics

Sex (male/female)	20/7
Age (yr)	68 (range: 45-91)
Tumor location
Right colon	7
Left colon	15
Rectum	5
Histological type
Well-differentiated adenocarcinoma	7
Moderately-differentiated adenocarcinoma	19
Mucinous adenocarcinoma	1
Tumor size (cm)	5.2 ± 1.7
Tumor depth (T1/T2/T3/T4a/T4b)	0/1/15/6/5
Stage (UICC-7th)
I/II/IIIa/IIIb/IIIc/IV	1/12/0/4/2/8

Table 2 Correlation coefficients (r) between levels of SphK1, LPAR2, and each S1P receptor

		LPAR2	SPHK1	S1PR1	S1PR2	S1PR3
LPAR2	Pearson correlation	1	0.7841	0.6381	0.6391	0.620
	Sig. (2-tailed)		0.000	0.000	0.000	0.001
SPHK1	Pearson correlation	0.7841	1	0.6611	0.577	0.553
	Sig. (2-tailed)	0.000	.	0.000	0.002	0.003
S1PR1	Pearson correlation	0.6381	0.6611	1	0.587	0.8151
	Sig. (2-tailed)	0.000	0.000	.	0.001	0.000
S1PR2	Pearson correlation	0.6391	0.577	0.587	1	0.576
	Sig. (2-tailed)	0.000	0.002	0.001	.	0.002
S1PR3	Pearson correlation	0.620	0.553	0.8151	0.576	1
	Sig. (2-tailed)	0.001	0.003	0.000	0.002	.

¹Correlation is significant at the 0.01 level (2-tailed).