Mechanisms of intrahepatic triglyceride accumulation

Table 1 Overview on potential causes of fatty liver (adapted from[2,121,122])

Etiologies of fatty liver disease
Frequent causes:
Non-alcoholic fatty liver disease
Alcoholic fatty liver disease
Chronic hepatitis C virus infection
Drug-induced steatosis
Less common or rare causes:
Inborn errors of metabolism (Wilson disease, abetalipoproteinemia, tyrosinaemia, hypobetalipoproteinemia)
Lipodystrophy (congenital or acquired)
Total parenteral nutrition
Surgical procedures (e.g., biliopancreatic diversion extensive small bowel resection)

Table 2 Overview on drug-induced micro- or macrovesicular forms of fatty liver disease (adapted from[108,123])

Causes of drug-induced fatty liver disease
Predominantly microvesicular pattern:
Tetracyclin
Valproic acid
Amiodarone
Glucocorticoids
5-FU
Margosa oil
Predominantly macrovesicular pattern:
Acetylsalicylic acid (intoxication)
Tamoxifen
Mixed pattern:
Antiretroviral agents (e.g., didanosine, stavudine)
Methotrexate