Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer

Table 1 Significantly mutated genes identified using a combined exome sequencing data from 629 gastric cancer patients

Gene	Nonsilent mutationsfrom 629 GCs	P value	Q value
TP53	276	0	0
KRAS	41	0	0
RHOA	34	0	0
PCDHGA6	34	0	0
DDI1	27	0	0
KRT73	24	0	0
OR10J3	21	0	0
GHSR	20	0	0
DHFR	4	0	0
CDH1	86	6.00 × 10-15	1.13 × 10-11
PREX2	94	2.23 × 10-10	3.82 × 10-7
PIK3CA	100	1.75 × 10-9	2.75 × 10-6
GLI3	81	8.46 × 10-9	1.23 × 10-5
KIF2B	46	2.62 × 10-8	3.53 × 10-5
GRM8	47	1.73 × 10-7	2.18 × 10-4
RPL22	16	2.92 × 10-7	3.44 × 10-4
DNAH5	132	3.92 × 10-7	4.20 × 10-4
EPB41L3	48	4.07 × 10-7	4.20 × 10-4
DCAF12L1	29	4.23 × 10-7	4.20 × 10-4
PLCL1	38	4.79 × 10-7	4.51 × 10-4

GC: Gastric cancer.