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©The Author(s) 2016.
World J Gastroenterol. Jun 21, 2016; 22(23): 5400-5405
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5400
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5400
Table 1 Patient characteristics
Patient characteristics | n (%) |
Total number | 10.0 |
Average age (yr) | 65.4 |
Gender | |
Female | 2 (20) |
Male | 8 (80) |
Location | |
Colon | 8 (80) |
Rectum | 2 (20) |
UICC | |
1 + 2 + 3 | 0 (0) |
4 | 10 (100) |
Metastases | |
Liver | 6 (60) |
Lung | 8 (80) |
Lymph nodes | 5 (50) |
Prior ctx regimen | |
3 | 7 (70) |
4 | 2 (20) |
5 | 0 (0) |
6 | 1 (10) |
Table 2 Detailed description of patients at therapy start
Patient | Age | Gender | Primary | UICC | Liver metastases | Lunge metastases | Number of pre-therapies |
1 | 68 | M | Sigma | IV | 1 | 1 | 3 |
2 | 52 | M | Colon desc. | IV | 0 | 1 | 3 |
3 | 51 | M | Sigma | IV | 1 | 1 | 3 |
4 | 81 | M | Rectum | IV | 1 | 1 | 3 |
5 | 59 | F | Colon desc. | IV | 1 | 1 | 3 |
6 | 74 | M | Sigma | IV | 0 | 1 | 3 |
7 | 74 | M | Rectum | IV | 1 | 0 | 4 |
8 | 65 | F | Sigma | IV | 1 | 1 | 6 |
9 | 69 | M | Sigma | IV | 0 | 1 | 3 |
10 | 61 | M | Colon desc. | IV | 0 | 0 | 4 |
Table 3 Detailed treatment description of patients
Table 4 Adverse events (CTC AE3.0)
Patient | I°-II° | III°-IV° | Total |
Fatigue | 70% (7/10) | 30% (3/10) | 100% |
Nausea | 20% (2/10) | 0% (0/10) | 20% |
Emesis | 20% (2/10) | 10% (1/10) | 30% |
Diarrhea | 40% (4/10) | 0% (0/10) | 40% |
Mukositis | 30% (3/10) | 10% (1/10) | 40% |
Rash | 20% (2/10) | 0% (0/10) | 20% |
HFS | 30% (3/10) | 0% (0/10) | 30% |
PNP | 20% (2/10) | 0% (0/10) | 20% |
Pain | 20% (2/10) | 10% (1/10) | 30% |
Weight loss | 10% (1/10) | 0% (0/10) | 10% |
Infection | 20% (2/10) | 0% (0/10) | 20% |
Anemia | 40% (4/10) | 20% (2/10) | 60% |
Thrombopenia | 30% (3/10) | 10% (1/10) | 40% |
Leucopenia | 20% (2/10) | 10% (1/10) | 30% |
- Citation: Martchenko K, Schmidtmann I, Thomaidis T, Thole V, Galle PR, Becker M, Möhler M, Wehler TC, Schimanski CC. Last line therapy with sorafenib in colorectal cancer: A retrospective analysis. World J Gastroenterol 2016; 22(23): 5400-5405
- URL: https://www.wjgnet.com/1007-9327/full/v22/i23/5400.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i23.5400