Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma

Table 1 Baseline characteristics of patients included in our study

Characteristic	HEHE (n = 25)	Hemangioma and FNH (n = 45)
Age (yr)
mean ± SD	46 ± 14	46 ± 14
Range	24-78	23-74
Male/female	8/17	9/36
Number of FLL (single/multiple)	3/22	0/45
Histological results
hepatic surgery	6	0
core needle biopsy	19	45

HEHE: Hepatic epithelioid haemangioendothelioma; FNH: Focal nodular hyperplasia; FLL: Focal liver lesions.

Table 2 Conventional ultrasound features of hepatic epithelioid haemangioendothelioma and hemangioma/Focal nodular hyperplasia n (%)

Characteristic	HEHE (n = 25)	Hemangioma/FNH(n = 45)
Number of nodules (single/multiple)	3/22	0/45
Size of nodules (mm)
mean ± SD	41.5 ± 25.6	50.4 ± 25.7
range	12-120	20-138
Echogenicity of nodules
Hyperechoic	2 (8)	19 (42.2)
Hypoechoic	23 (92)	9 (20.0)
Isoechoic	0	17 (37.8)
Homogenous/heterogeneous	9/16	15/30

HEHE: Hepatic epithelioid haemangioendothelioma; FNH: Focal nodular hyperplasia.

Table 3 Contrast enhanced ultrasound imaging features of hepatic epithelioid haemangioendothelioma and multilocular hemangioma/ focal nodular hyperplasia n (%)

Characteristic	HEHE(n = 25 patients)	Hemangioma/FNH(n = 45 patients)
Arterial phase
Rim like hyperenhancement	18 (72)	0
Heterogeneously hyperenhancement	7 (28)	6 (13.3)
Peripheral nodular enhancement	0	All hemangioma
Central arterial blood supply		All FNH
Portal-venous phase
Hyperenhancement	0	100 (100.0%)
Hypoenhancement	25 (100)	0
Isoenhancement	0	0
Late phase
Hyperenhancement	0	45 (100.0%)
Hypoenhancement	25 (100)	0
Isoenhancement	0	0
Sensitivity
Rim like hyperenhancement	18/25 (72)	0
Hypoenhancement at portal venous phase	25/25 (100)	0
Central unenhanced area at late phase
Yes	18 (72)	13 (28.9)
No	7 (28)	32 (71.1)

CEUS: Contrast enhanced ultrasound; HEHE: Hepatic epithelioid haemangioendothelioma; FNH: Focal nodular hyperplasia.