Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2016; 22(19): 4741-4749
Published online May 21, 2016. doi: 10.3748/wjg.v22.i19.4741
Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma
Yi Dong, Wen-Ping Wang, Vito Cantisani, Mirko D’Onofrio, Andre Ignee, Lorenzo Mulazzani, Adrian Saftoiu, Zeno Sparchez, Ioan Sporea, Christoph F Dietrich
Yi Dong, Wen-Ping Wang, Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Vito Cantisani, Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, University Sapienza, 00185 Rome, Italy
Mirko D’Onofrio, Department of Radiology, GB Rossi University Hospital, University of Verona, 37121 Verona, Italy
Christoph F Dietrich, Andre Ignee, Medizinische Klinik 2, Caritas-Krankenhaus Bad Mergentheim, 97980 Bad Mergentheim, Germany
Lorenzo Mulazzani, Department of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, 40126 Bologna, Italy
Adrian Saftoiu, Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, 200349 Craiova, Romania
Adrian Saftoiu, Department of Endoscopy, Gastrointestinal Unit, Copenhagen University Hospital, DK-2730 Herlev, Denmark
Zeno Sparchez, Department of Gastroenterology, Institute for Gastroenterology and Hepatology, University of Medicine and Pharmacy, “Iuliu Hatieganu” Cluj-Napoca and Institute for Gastroenterology and Hepatology “O.Fodor”, 200349 Craiova, Romania
Ioan Sporea, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babes, 300041 Timisoara, Romania
Author contributions: Dietrich CF is accepting full responsibility for the conduct of the study, he and all others had access to the data, all had control of the decision to publish; Christoph F planned the study; Dietrich CF, Dong Y, D’Onofrio M, and Cantisani V drafted the manuscript; Dietrich CF and Dong Y performed the statistical analysis; each author made a statement that they approved the final draft submitted; all authors conducted the study, collected and/or interpreted data, and critically revised the manuscript for important intellectual content.
Institutional review board statement: This study was a Retrospective Study, Institutional review board statement was applicable to our current study.
Informed consent statement: This study was a Retrospective Study, patients Informed consent statement was applicable to our current study.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: Each author gives permission to the graphic designers to alter the visual aspect of figures, tables, or graphs.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Christoph F Dietrich, MD, PhD, MBA, Professor, Chief, Medizinische Klinik 2, Caritas Krankenhaus Bad Mergentheim Uhlandstr 7, D-97980 Bad Mergentheim, Germany. christoph.dietrich@ckbm.de
Telephone: +49-7931-582201 Fax: +49-7931-582290
Received: January 8, 2016
Peer-review started: January 10, 2016
First decision: February 18, 2016
Revised: March 15, 2016
Accepted: April 7, 2016
Article in press: April 7, 2016
Published online: May 21, 2016
Processing time: 129 Days and 13 Hours
Core Tip

Core tip: In this retrospective study, a large cohort of very rare histologically proven hemangioendothelioma (HEHE) was evaluated. Contrast-enhanced ultrasound (CEUS) allowed for improved detection of multilocular HEHE. HEHE showed typical enhancement patterns on CEUS. Therefore, CEUS can help to determine the malignant nature of HEHE.