Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma

Table 1 Clinical trials of antiviral therapy after curative treatment for hepatitis B virus-related hepatocellular carcinoma

					Effects of antiviral therapy
Author	Year	Study design	Treatment	Adjuvant therapy	Tumor-free survival	Overall survival
Interferon
Sun et al[39]	2006	RCT	Resection	Inteferon-α	Postponed	Improved
Lo et al[37]	2007	RCT	Resection	Inteferon-α2b	Not significant	Improved in stage III/IVA patients
Chen et al[42]	2012	RCT	Resection	Inteferon-α2b	Not significant	Not significant
Nucleos(t)ide analogues
Kubo et al[45]	2007	Prospective cohort	Resection	LAM (with ADV rescue)	Improved	ND
Kuzuya et al[48]	2007	Retrospective cohort	Resection or RFA	LAM (with ADV rescue)	Not significant	Improved (tendency)
Yoshida et al[49]	2008	Retrospective cohort	RFA	LAM (with ADV rescue)	Not significant	Not significant
Chuma et al[11]	2009	Retrospective cohort	Resection or RFA	LAM (with ADV rescue) or ETV	Improved	ND
Koda et al[50]	2009	Cohort	Resection or RFA	LAM (with ADV rescue) or ETV	Not significant	Improved
Li et al[51]	2010	Prospective cohort	Resection	LAM (with ADV rescue)	Not significant	Improved
Chan et al[52]	2011	Retrospective cohort	Resection	LAM or ETV	Improved	Improved
Urata et al[44]	2012	Retrospective cohort	Resection	LAM (with ADV rescue) or ETV	Improved	Improved
Wu et al[53]	2012	Cohort	Resection	LAM, ETV, telbivudine	Improved	Improved
Su et al[54]	2013	Retrospective cohort	Rection	LAM or ETV or Pegylated interferon	Improved	Improved
Ke et al[55]	2013	Retrospective cohort	Resection	LAM	Not significant	Improved
Yin et al[56]	2013	Cohort including RCT	Resection	LAM (with ADV or ETV rescue)	Improved	Improved
Nishikawa et al[57]	2014	Retrospective cohort	Resection or RFA or PEI	LAM (with ADV rescue) or ETV	Not significant	Improved

RCT: Randomised clinical trial; RFA: Radiofrequency ablation therapy; PEI: Percutaneous ethanol injection; LAM: Lamivudine; ADV: Adefovir dipivoxil; ETV: Entecavir; ND: Not determined.