Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray

Table 1 Characteristics of tissue samples

Characteristic	Benign GISTs(n = 9)	Borderline GISTs(n = 14)	Malignant GISTs(n = 31)
Age (yr)
Median	68	58	58
Gender
Male	4	6	19
Female	5	8	11
Risk
Low	6	6	3
Intermediate	3	4	2
High	0	4	26

GISTs: Gastrointestinal stromal tumors.

Table 2 MicroRNA signatures between the benign gastrointestinal stromal tumors (B group) and the malignant gastrointestinal stromal tumors (M group)

ID	logFC	AveExpr	t	P value	Adjusted P value
hsa-let-7c	2.645556	20.57949	4.561671	4.20E-05	0.035449
MIR-218	4.103333	24.58974	4.293033	9.85E-05	0.041616
MIR-34C-5P	-3.13333	31.12308	-3.89399	0.000339	0.091870
MIR-488#	3.141111	32.27179	3.811858	0.000435	0.091870
MIR-4683	1.455556	29.83077	3.452312	0.00126	0.199198
MIR-4773	-2.89333	32.37436	-3.41224	0.001414	0.199198

Negative numbers indicate that the fold change is lower in the B group than in the M group. LogFC: Logarithm fold change; Aveexpr: Average expression.

Table 3 MiRNA signatures between the borderline gastrointestinal stromal tumors (borderline group) and malignant gastrointestinal stromal tumors (M group)

ID	logFC	AveExpr	t	P value	Adjusted P value	B
MIR-29B-2#	1.887619	26.27273	4.791486	1.67E-05	0.009785	2.889621
hsa-let-7c	2.118571	20.51591	4.449458	5.20E-05	0.009785	1.850695
MIR-891b	3.170952	32.94773	4.420680	5.71E-05	0.009785	1.764525
MIR-218	3.579524	24.39773	4.399150	6.13E-05	0.009785	1.700197
MIR-204	3.238095	25.98636	4.368453	6.78E-05	0.009785	1.608688
MIR-204-3P	2.390000	29.77955	4.360826	6.95E-05	0.009785	1.585990
MIR-628-5P	1.875238	26.75000	4.185139	0.000123	0.013800	1.067600
MIR-196a	-3.906670	25.33636	-4.165320	0.000131	0.013800	1.009689
MIR-744	1.590476	24.82727	4.120092	0.000151	0.013983	0.877951
MIR-29C#	1.350476	26.76364	4.070312	0.000177	0.013983	0.733696
MIR-625	1.648095	27.10227	4.061304	0.000182	0.013983	0.707679

Negative numbers indicate that the fold change is lower in the borderline group than in the M group. LogFC: Logarithm fold change; AveExpr: Average expression.

Table 4 miRNA signatures between the benign gastrointestinal stromal tumors or borderline gastrointestinal stromal tumors (benign and borderline group) and the malignant gastrointestinal stromal tumors (M group)

ID	logFC	AveExpr	t	P value	Adjusted P value	B
hsa-let-7c	2.324783	20.18113	5.938844	1.86E-07	0.000157	7.046674
MIR-218	3.784493	23.89434	5.519007	8.86E-07	0.000375	5.587287
MIR-34C-5P	-2.908700	31.66226	-5.032010	5.24E-06	0.001477	3.931173
MIR-628-5P	1.903188	26.52075	4.863745	9.58E-06	0.002023	3.370903
MIR-204-3P	2.309565	29.53774	4.525668	3.14E-05	0.004925	2.268094
MIR-204	2.973188	25.72642	4.455823	4.00E-05	0.004925	2.044513
MIR-891b	2.787101	32.74717	4.417100	4.57E-05	0.004925	1.921237
MIR-488#	2.648841	31.84717	4.392406	4.98E-05	0.004925	1.842883
MIR-196a	-3.389280	25.56415	-4.376970	5.25E-05	0.004925	1.794012
MIR-145	1.505217	17.88679	4.290314	7.05E-05	0.005869	1.521146
MIR-891a	1.900870	29.41509	4.266462	7.64E-05	0.005869	1.446506

Negative numbers indicate that the fold change is lower in the BB group than in the M group. LogFC: Logarithm fold change; AveExpr: Average expression.