Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection

doi:10.3748/wjg.v21.i18.5496

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May 14, 2015 (publication date) through Feb 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. May 14, 2015; 21(18): 5496-5504
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5496

Table 1 Clinical and laboratory characteristics of patients n (%)

	ESRD	Controls	P value
	(n = 39)	(n = 109)
Age, median (range)	52 (25-69)	46 (17-67)	0.013
Gender, F/M	15/24 (38.5/61.5)	55/54 (50.5/49.5)	0.262
Fibrosis stage before treatment according to Metavir score
F0	2 (5.1)	3 (2.8)	0.072
F1	12 (30.8)	25 (22.9)
F2	6 (15.4)	21 (19.3)
F3	1 (2.6)	21 (19.3)
F4	8 (20.5)	31 (28.4)
F unknown	10 (25.6)	8 (7.3)
BMI, average (mean ± SD)	24 ± 4.1	25 ± 4.0	0.071
Type 2 diabetes	5 (12.8)	12 (11.0)	0.773
Initial ALT (IU/L), average (mean ± SD)	57 ± 54	105 ± 87	< 0.001
Initial viral load (IU/mL x 1000), median (IQR)	193 (16-810)	541 (163-1853)	0.003
RVR	20 (52.6)	39 (36.1)	0.074
EVR	29 (74.4)	60 (55.0)	0.038
SVR	25 (64.1)	55 (50.5)	0.190
Premature termination of treatment	14 (35.9)	44 (40.4)	0.704
IL28B CC genotype	11 (28.2)	21 (19.3)	0.262
IFNL4 TT genotype	11 (28.9)	21 (19.3)	0.370
Initial viral load < 600000 IU/mL	28 (71.8)	51 (46.8)	0.009
History of kidney transplant	29 (74.4)	NA	NA
Concurrent treatment with ribavirin	23 (59.0)	109 (100.0)	< 0.001

Controls: HCV patients with normal pretreatment renal function; ESRD: HCV patients with end-stage renal disease treated with haemodialysis; BMI: Body mass index; RVR: Rapid virological response; EVR: Early virological response; SVR: Sustained virological response; HCV: Hepatitis C virus; NA: Not applicable.

Table 2 Initial viral load and IL28B rs12979860 genotype in patients grouped according to their sustained virological response achievement n (%)

Patients	SVR	IVL (IU/mL)	IL28B rs12979860 genotype
Patients	SVR	IVL (IU/mL)	CT or TT	CC
ESRD	Yes	< 600000	14 (58)	10 (42)
	Yes	> 600000	0 (0)	1 (100)
	No	< 600000	4 (100)	0 (0)
	No	> 600000	10 (100)	0 (0)
controls	Yes	< 600000	26 (84)	5 (16)
	Yes	> 600000	10 (42)	14 (58)¹
	No	< 600000	18 (90)	2 (10)
	No	> 600000	33 (97)	1 (3)

¹Includes the patient with IL28B CT and IFNL4 TT/TT. IVL: Initial viral load; ESRD: End-stage renal disease; SVR: Sustained virological response.

Citation: Sperl J, Frankova S, Senkerikova R, Neroldova M, Hejda V, Volfova M, Merta D, Viklicky O, Spicak J, Jirsa M. Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection. World J Gastroenterol 2015; 21(18): 5496-5504
URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5496.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5496