Prognostic significance of preoperative platelet count in patients with gallbladder cancer

Table 1 Association of platelet count with the parameters of 223 gallbladder cancer patients n (%)

Parameter	Cases	PLT
		mean ± SD	P value	≤178	>178	P value
Gender			0.921			0.985
Men	67 (30.0)	219 ± 91		25%	42%
Women	156 (70.0)	224 ± 91		58%	98%
Age			0.573			0.379
> 65	99 (44.4)	226 ± 90		40%	59%
≤ 65	124 (55.6)	217 ± 92		43%	81%
Comorbidity			0.250			0.101
Yes	84 (37.7)	214 ± 97		37%	47%
No	139 (62.3)	227 ± 87		46%	93%
Gallstone history			0.358			0.361
Yes	119 (53.4)	231 ± 95		41%	78%
No	104 (46.6)	212 ± 85		42%	62%
ABO blood group			0.713			0.189
A	59 (26.4)	211 ± 95		26%	33%
B	82 (36.8)	228 ± 84		23%	59%
O	27 (12.1)	224 ± 98		11%	16%
AB	55 (24.7)	224 ± 93		23%	32%
Tumor location			0.422			< 0.001
Neck	90 (40.4)	279 ± 83		9%	81%
Other	133 (59.6)	184 ± 75		74%	59%
TNM stage			0.006			< 0.001
0-II	49 (22.0)	161 ± 72		34%	15%
III-IV	174 (78.0)	239 ± 88		49%	125%
Nevin stage			0.011			< 0.001
I-III	70 (31.4)	160 ± 69		49%	21%
IV-V	153 (68.6)	251 ± 85		35%	119%
Tumor differentiation			0.771			< 0.001
Well and moderately	108 (48.4)	187 ± 84		60%	48%
Poorly and undifferentiated	115 (51.6)	255 ± 85		23%	92%
Lymph node metastasis			0.013			< 0.001
Yes	149 (66.8)	251 ± 86		33%	116%
No	74 (33.2)	163 ± 69		50%	24%
Pathological type			0.049			0.027
Adenocarcinoma	183 (82.1)	226 ± 88		62%	121%
Other types	40 (17.9)	205 ± 104		21%	19%

GBC: Gallbladder cancer; PLT: Platelet count.

Table 2 Univariate analysis of the factors associated with the gallbladder cancer survival rate

Variable	HR (95%CI)	P value
Gender	0.940 (0.677-1.306)	0.712
Male
Female
Age (yr)	1.137 (0.840-1.539)	0.408
≤ 65
> 65
Gallstone history	1.066 (0.923-1.232)	0.383
Yes
No
Comorbidity	0.912 (0.665-1.251)	0.567
Yes
No
Tumor location	8.910 (6.236-12.730)	< 0.001
Neck
Other (body, bottom)
Tumor differentiation	3.209 (2.325-4.427)	< 0.001
Well and Moderately
Poorly and undifferentiated
TNM stage	11.003 (5.896-20.535)	< 0.001
0-II
III-IV
Nevin stage	10.642 (6.612-17.127)	< 0.001
I-III
IV-V
Lymph node metastasis	9.775 (6.224-15.352)	< 0.001
Yes
No
Pathological type	0.708 (0.469-1.070)	0.101
Adenocarcinoma
Other types
PLT	3.333 (2.351-4.726)	< 0.001
≤ 178
> 178

GBC: Gallbladder cancer; PLT: Platelet count.

Table 3 Multivariate Cox regression analysis of overall survival in gallbladder cancer patients

Variable	Characteristic	HR (95%CI)	P value
Lymph node metastasis	Yes	1.795 (1.170-2.755)	0.007
	No
TNM stage	0-II	3.349 (1.436-7.814)	0.005
	III-IV
PLT	≤ 178	1.541 (1.038-2.287)	0.032
	> 178
Tumor location	Neck	6.200 (4.120-9.329)	< 0.001
	Other (body, bottom)

GBC: Gallbladder cancer; PLT: Platelet count.