Wang RT, Zhang LQ, Mu YP, Li JB, Xu XS, Pang Q, Sun LK, Zhang X, Dong SB, Wang L, Liu C. Prognostic significance of preoperative platelet count in patients with gallbladder cancer. World J Gastroenterol 2015; 21(17): 5303-5310 [PMID: 25954104 DOI: 10.3748/wjg.v21.i17.5303]
Corresponding Author of This Article
Chang Liu, MD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. eyrechang@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
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Wang RT, Zhang LQ, Mu YP, Li JB, Xu XS, Pang Q, Sun LK, Zhang X, Dong SB, Wang L, Liu C. Prognostic significance of preoperative platelet count in patients with gallbladder cancer. World J Gastroenterol 2015; 21(17): 5303-5310 [PMID: 25954104 DOI: 10.3748/wjg.v21.i17.5303]
Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an 710061, Shaanxi Province, China
Yi-Ping Mu, Department of Medical Record Information Office, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an 710061, Shaanxi Province, China
Jian-Bo Li, Department of Hepatobiliary Surgery, the West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wang RT and Zhang LQ contributed equally to this work; Wang RT and Liu C designed the research; Wang RT and Zhang LQ wrote the paper; Mu YP and Li JB collected the patient’s clinical data; Sun LK, Zhang X and Dong SB analyzed the data; Xu XS, Pang Q and Wang L revised the paper; all authors read and approved the final manuscript.
Supported by Hospital Foundation of the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine (Xi’an, China), No. 2013YK36.
Ethics approval: The study was reviewed and approved by the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine Institutional Review Board.
Informed consent: Informed written consent was provided by each participant or the participant’s legal guardian prior to enrollment in the study.
Conflict-of-interest: The authors have no conflicts of interest related to the manuscript.
Data sharing: No additional data are available.
Correspondence to: Chang Liu, MD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. eyrechang@126.com
Telephone: +86-29-85323890 Fax: +86-29-85323890
Received: October 25, 2014 Peer-review started: October 28, 2014 First decision: November 14, 2014 Revised: December 5, 2014 Accepted: February 11, 2015 Article in press: February 11, 2015 Published online: May 7, 2015 Processing time: 199 Days and 13.1 Hours
Abstract
AIM: To investigate the prognostic value of preoperative platelet count (PLT) in patients with primary gallbladder cancer (GBC).
METHODS: The clinical data of 223 GBC patients after surgery was retrospectively reviewed. A receiver operating characteristic (ROC) curve was plotted to verify the optimum cutoff point for PLT. Univariate and multivariate survival analyses were performed to identify the factors associated with the prognosis.
RESULTS: The ROC curve showed that the optimum cutoff point for PLT was 178 × 109/L, and the entire cohort was stratified into group A with PLT > 178 × 109/L and group B with PLT ≤ 178 × 109/L. Group A had a better survival than group B (P < 0.001). There was an obvious difference between the two groups in terms of the differentiation degree, advanced tumor stage, lymph node metastasis (P < 0.001) and pathological type (P < 0.05). The univariate analysis demonstrated that tumor location, differentiation degree, TNM stage, Nevin stage, lymph node metastasis and PLT were associated with overall survival (P < 0.001). In the multivariate analysis, PLT (P = 0.032), lymph node metastasis (P = 0.007), tumor location (P < 0.001) and TNM stage (P = 0.005) were independent prognostic factors.
CONCLUSION: PLT is closely correlated with GBC prognosis and could be used to identify the population with a poorer prognosis after surgery.
Core tip: Platelet count (PLT) is implicated with a poor prognosis in many types of malignancies. Its prognostic value has not been reported in gallbladder carcinoma (GBC). The most important finding in this study was that PLT was correlated with GBC prognosis, and was an independent prognostic factor after surgery.
