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Apr 7, 2015 (publication date) through Nov 11, 2025
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 3786-3800
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3786
Table 1 Antiviral interferon-stimulated genes targeting different steps of the hepatitis C virus life cycle
Gene symbolPhases of HCV life cycle targeted by ISGsInfection or replicon for studiesOverexpression or knockdown of ISGs for testsRef.
IFITM1EntryInfectionoe/kd[158]
ReplicationInfectionoe/kd[159]
ReplicationRepliconkd[147]
IFITM3TranslationRepliconoe[161]
ReplicationRepliconoe[160]
ReplicationRepliconoe/kd[147]
DDIT4TranslationInfection/repliconoe[144]
IFI44LTranslationInfection/repliconoe[144]
IRF1TranslationInfection/repliconoe[144]
ReplicationRepliconoe[162]
IRF2TranslationInfection/repliconoe[144]
IRF7TranslationInfection/repliconoe[144]
MAP3K14TranslationInfection/repliconoe[144]
MDA5TranslationInfection/repliconoe[144]
NT5C3TranslationInfection/repliconoe[144]
RIG-ITranslationInfection/repliconoe[144]
OASLTranslationInfectionoe[144]
ReplicationRepliconoe[152]
RNaseLReplicationRepliconoe/kd[147]
ReplicationInfectionoe[153]
ADAR1ReplicationRepliconkd[163]
GBP-1ReplicationRepliconoe/kd[162]
IFI27ReplicationRepliconoe/kd[162]
IFI6ReplicationRepliconoe/kd[162]
IFIT1ReplicationInfectionoe/kd[162]
IFIT3ReplicationRepliconkd[147]
IRF9ReplicationRepliconoe[162]
ISG20ReplicationRepliconoe[164]
MxAReplicationRepliconoe[162]
NOS2ReplicationRepliconoe/kd[147]
OASReplicationRepliconoe[162]
PLSCR1ReplicationRepliconoe/kd[147]
TRIM14ReplicationRepliconoe/kd[147]
ViperinReplicationRepliconoe[164]
ReplicationRepliconoe[165]
ReplicationInfection/repliconoe[155]
ReplicationInfectionkd[156]
TetherinReleaseInfectionoe[166]
HCV: Hepatitis C virus; ISGs: Interferon-stimulated genes; Infection or replicon: The functions of ISGs were studied by using infectious culture system (infection) or subgenomic replicon (replicon); oe or kd: The functions of ISGs were identified by using overexpression (oe) or knockdown (kd) of indicated ISGs in cells.
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