Hypoxia and fatty liver

doi:10.3748/wjg.v20.i41.15087

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Nov 7, 2014 (publication date) through Oct 29, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2014; 20(41): 15087-15097
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087

Table 1 Downstream target genes of hypoxia-inducible factor isoforms

Hypoxia inducible gene	Function	HIF-1 target gene	HIF-2 target gene
Oxygen supply
Erythropoietin	Erythropoiesis	+	+
VEGF	Angiogenesis	+	+
iNOS	Vasodilation	+	-
PAI-1	Blood flow	+	+
ANGPTL2	Vascular remodeling	-	+
Cellular metabolism
HK1/2	Glycolysis	+	-
PGK1	Glycolysis	+	-
LDHA	Glycolysis	+	-
GLUT-1	Glucose transporter	+	+
ADRP/ADFP	Lipid metabolism	+	+
DEC1/2	Lipid metabolism	+	-
ANGPTL3	Lipid metabolism	+	+
Cell cycle
TGFα	Growth factor	-	+
Cyclin D1	Cell cycle progression	-	+
BNIP3	Apoptosis	+	-
Oxidative stress
HO-1	Anti-oxidant	+	-
SOD1/2	Anti-oxidant		+
Catalase	Anti-oxidant		+
GPX1	Anti-oxidant		+

HIF: Hypoxia-inducible factor.

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Citation: Suzuki T, Shinjo S, Arai T, Kanai M, Goda N. Hypoxia and fatty liver. World J Gastroenterol 2014; 20(41): 15087-15097
URL: https://www.wjgnet.com/1007-9327/full/v20/i41/15087.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i41.15087