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World J Gastroenterol. Nov 7, 2014; 20(41): 15087-15097
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087
Hypoxia and fatty liver
Tomohiro Suzuki, Satoko Shinjo, Takatomo Arai, Mai Kanai, Nobuhito Goda, Department of Life Science and Medical BioScience, Waseda University School of Advanced Science and Engineering, Tokyo 162-8480, Japan
Author contributions: Suzuki T and Goda N designed and wrote the paper; Shinjo S, Arai T and Kanai M wrote the paper and discussed the body of the paper with Suzuki T and Goda N.
Supported by Grant from Waseda University (in part); a Grant For Special Research Projects from the MEXT-Supported Program for the Strategic Research Foundation at Private; and a Grant-in-Aid for Scientific Research (C) from MEXT
Correspondence to: Nobuhito Goda, MD, PhD, Department of Life Science and Medical BioScience, Waseda University School of Advanced Science and Engineering, TWIns 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan. goda@waseda.jp
Telephone: +81-3-53697319 Fax: +81-3-53697319
Received: October 25, 2013
Revised: February 14, 2014
Accepted: May 28, 2014
Published online: November 7, 2014
Processing time: 381 Days and 3.5 Hours
Revised: February 14, 2014
Accepted: May 28, 2014
Published online: November 7, 2014
Processing time: 381 Days and 3.5 Hours
Core Tip
Core tip: Hypoxia occurs in the development and progression of fatty liver disease. Recent reports have shed light on the pathological significance of hypoxia inducible factors (HIFs), master regulators of the hypoxic response, with regard to their regulation of lipid metabolism in context- and isoform-dependent manners. In this review, we summarize recent findings on the various roles of HIF-dependent regulation in fatty liver disease.