Clinical and endoscopic characteristics of drug-induced esophagitis

Table 1 Demographic features and clinical symptoms of patients diagnosed with drug-induced esophagitis n (%)

Characteristics
Age(yr)	mean ± SD	43.9 ± 18.9
Sex	Male/female	28/50
Symptom	Chest pain	56 (71.8)
	Odynophagia	30 (38.5)
	Dysphagia	23 (29.5)
	Vomiting	6 (7.7)
	Melena	2 (2.6)

Table 2 Endoscopic features of patients diagnosed with drug-induced esophagitis

Feature		n (%)
Location	Proximal	3 (3.8)
	Middle	61 (78.2)
	Distal	14 (17.9)
Endoscopic findings	Ulcers	64 (82.1)
	Bleeding	19 (24.4)
	Erosions	14 (17.9)
	Coating	4 (5.1)
	Pill	3 (3.8)
	Stricture	2 (2.6)
	Kissing ulcers	34 (43.6)

Table 3 Causative drugs of patients diagnosed with drug-induced esophagitis

Drug	n (%)
Antibiotics	28 (35.9)
NSAID	27 (34.6)
Anti-hypertensive	9 (11.5)
Acetaminophen	7 (9.0)
Oral hypoglycemic	4 (5.1)
Bisphosphonate	4 (5.1)
Ascorbic acid	2 (2.6)
Warfarin	2 (2.6)
Other drugs	4 (5.1)

NSAID: Non-steroidal anti-inflammatory drug.

Table 4 Proportion of antibiotics and non-steroidal anti-inflammatory drugs between both age groups

	Age		Total	P value
	< 45 yr	≥ 45 yr
Antibiotics				0.020
(+)	20	8	28
(-)	22	28	50
Total	42	36	78
NSAID
(+)	12	15	27	0.226
(-)	30	21	51
Total	42	36	78

NSAID: Non-steroidal anti-inflammatory drug.

Table 5 Pathological findings of drug-induced esophagitis group and reflux esophagitis group n (%)

	Drug-induced esophagitis	Reflux esophagitis	P value
	(n = 17)	(n = 19)
Basal cell hyperplasia	6 (35.3)	5 (26.3)	0.559
Papillary elongation	5 (29.4)	11 (57.9)	0.086
Dilated intercellular spaces	11 (64.7)	8 (42.1)	0.175
Cell vacuolization	13 (76.5)	9 (47.4)	0.074