MiRNA as potential biomarkers and therapeutic targets for gastric cancer

Table 1 Gastric cancer-associated microRNAs

	Functions	Targets	Ref.
Upregulated miRNAs
miR-15b, miR-16	Cell survival	BCL2	[47]
miR-21	Cell proliferation, invasion	PTEN	[49]
		PDCD4	[50]
miR-23a	Cell proliferation	IRF1, IL6R	[51]
miR-27a	Cell proliferation	PROHIBITIN	[52]
miR-43c	Epigenetic regulation	VEZT	[53]
miR-106a	Cell cycle regulation	RB1	[34]
miR-106b-25 cluster	Cell cycle arrest, apoptosis	E2F1	[54]
		p57, p21, p27	[55]
miR-107	Invasion, metastasis	DICER1	[56]
miR-130b	Apoptosis, epigenetic regulation	BIM, RUNX3	[57]
miR-150	Cell proliferation	EGR2	[58]
miR-223	Invasion, metastasis	EPB41L3	[59]
Downregulated miRNAs
let-7a	Cell proliferation	RAB40C	[60]
miR-9	Cell proliferation	NFkB	[61]
	Cell proliferation, cell cycle regulation	CDX2	[62]
miR-34b	Cell proliferation, transcription,	NOTCH1, c-Myc	[63]
	epigenetic regulation	BCL2, SIRT1
miR-124a	Cell cycle arrest	CDK6	[64]
miR-126	Cell cycle arrest	CRK	[65]
miR-129-2	Cell proliferation, differentiation, epigenetic regulation	SOX4	[66]
miR-143	Cell proliferation	AKT	[17]
miR-145	Cell proliferation	IRS-1	[17]
miR-146a	Invasion, migration	EGFR, IRAK1	[67]
miR-148b	Cell proliferation	CCKBR	[68]
miR-181c	Transcriptional activation	NOTCH4, K-ras	[30]
miR-200 family	Cell proliferation, invasion, migration	ZEB2, E-cadherin	[69]
miR-212	Cell proliferation	MeCP2	[29]
miR-218	Invasion, metastasis	ROBO1 receptor	[70]
	Transcriptional activation	NFκB	[12]
miR-375	Cell survival	PDK1, 14-3-3zeta	[71]
	Cell proliferation	JAK2	[72]
miR-451	Cell proliferation	MIF	[73]