Study of detection times for liver stiffness evaluation by shear wave elastography

Table 1 Comparison of liver stiffness values obtained from different valid measurements of shear wave elastography in patients with chronic hepatitis B at different pathological stages

Stage	n	1 VM (kPa)	2 VMs (kPa)	3 VMs (kPa)	5 VMs (kPa)	10 VMs (kPa)	F	P
F0	13	6.95 ± 2.01	6.87 ± 1.83	6.90 ± 1.88	6.95 ± 1.93	7.15 ± 1.89	0.043	0.996
F1	33	7.12 ± 1.72	7.24 ± 1.72	7.21 ± 1.74	7.10 ± 1.78	7.04 ± 1.70	0.075	0.99
F2	24	9.37 ± 3.87	9.18 ± 3.68	9.19 ± 3.81	9.18 ± 3.81	9.19 ± 3.53	0.012	1
F3	21	11.91 ± 3.88	11.78 ± 4.04	11.83 ± 4.07	11.94 ± 4.17	12.00 ± 4.02	0.01	1
F4	21	19.30 ± 7.63	19.40 ± 7.36	19.54 ± 7.43	19.73 ± 7.21	20.25 ± 7.22	0.054	0.995

VMs: Valid measurements.

Table 2 Correlation between liver stiffness values obtained from different valid measurements at different pathological stages

Stage	n	ICC	95%CI
F0	13	0.995	0.988-0.998
F1	33	0.993	0.988-0.996
F2	24	0.996	0.993-0.998
F3	21	0.994	0.989-0.997
F4	21	0.996	0.992-0.998
Overall	112	0.998	0.997-0.998

ICC: Intraclass correlation coefficient.

Table 3 Area under the receiver operating characteristic curve of the elastic modulus of the liver obtained from different valid measurements of shear wave elastography at different pathological stages

Stage	1 VM		2 VMs		3 VMs		5 VMs		All 10 VMs
	ROC	95%CI	ROC	95%CI	ROC	95%CI	ROC	95%CI	ROC	95%CI
F0-1234	0.772 (0.683-0.846)		0.782 (0.694-0.854)		0.775 (0.687-0.849)		0.763 (0.674-0.839)		0.740 (0.649-0.818)
F01-234	0.862 (0.784-0.920)		0.855 (0.775-0.914)		0.852 (0.772-0.912)		0.858 (0.779-0.916)		0.866 (0.789-0.923)
F012-34	0.896 (0.824-0.945)		0.899 (0.827-0.948)		0.902 (0.831-0.950)		0.907 (0.838-0.954)		0.909 (0.840-0.955)
F0123-4	0.919 (0.852-0.962)		0.929 (0.865-0.969)		0.934 (0.871-0.972)		0.941 (0.880-0.977)		0.949 (0.891-0.982)

VMs: Valid measurements; AUROC: Area under the receiver operating characteristic curve.

Table 4 Comparison of area under the receiver operating characteristic curve of the elastic modulus of the liver obtained from different valid measurements of shear wave elastography at different pathological stages

Different VMs	F0-1234		F01-234		F012-34		F0123-4
	Difference	P	Difference	P	Difference	P	Difference	P
1 VM vs 2 VMs	0.001	0.618	0.008	0.323	0.003	0.703	0.010	0.267
1 VM vs 3 VMs	0.003	0.917	0.011	0.321	0.006	0.57	0.015	0.171
1 VM vs 5 VMs	0.009	0.800	0.005	0.682	0.012	0.297	0.022	0.068
1 VM vs 10 VMs	0.032	0.365	0.004	0.787	0.013	0.379	0.030	0.089
2 VMs vs 3 VMs	0.006	0.785	0.003	0.617	0.003	0.595	0.004	0.477
2 VMs vs 5 VMs	0.018	0.420	0.003	0.704	0.009	0.208	0.012	0.152
2 VMs vs 10 VMs	0.042	0.152	0.012	0.415	0.010	0.475	0.020	0.212
3 VMs vs 5 VMs	0.012	0.487	0.006	0.227	0.005	0.208	0.007	0.152
3 VMs vs 10 VMs	0.035	0.073	0.015	0.245	0.007	0.609	0.015	0.302
5 VMs vs 10 VMs	0.023	0.451	0.009	0.461	0.002	0.900	0.008	0.538

VMs: Valid measurements.