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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2014; 20(2): 525-531
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.525
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.525
Table 1 Types of surgery for colorectal liver metastasis
Type of surgery | n (%) | |
Major resection | Right hemihepatectomy | 5 (41.7) |
Minor resection | Segmentectomy | 6 (50.0) |
Left lateral sectionectomy | 1 (8.3) | |
Total | 12 |
Table 2 Summary of patient information
No. | Age (yr) | Sex | Comorbidity | Treatment modality | Location | Timing of metastasis | Recurrence | Results |
1 | 51 | M | RFA | Colon | Meta | Yes | S | |
2 | 60 | M | RFA | Colon | Meta | Yes | D | |
3 | 69 | M | Resection | Colon | Meta | Yes | D | |
4 | 76 | M | DM, HT | Resection | Rectum | Meta | Yes | D |
5 | 62 | M | RFA | Colon | Syn | No | S | |
6 | 61 | M | DM | RFA | Rectum | Meta | Yes | D |
7 | 70 | F | Resection | Colon | Meta | Yes | S | |
8 | 70 | M | Resection | Rectum | Meta | No | S | |
9 | 71 | F | Resection | Rectum | Meta | Yes | S | |
10 | 69 | F | DM, HT | Resection | Colon | Syn | Yes | S |
11 | 74 | F | Resection | Colon | Syn | No | S | |
12 | 71 | M | Resection | Colon | Meta | Yes | S | |
13 | 82 | M | Resection | Rectum | Meta | Yes | D | |
14 | 58 | F | RFA | Colon | Meta | No | S | |
15 | 60 | M | RFA | Colon | Syn | Yes | D | |
16 | 56 | F | RFA | Colon | Meta | Yes | S | |
17 | 56 | M | RFA | Colon | Meta | Yes | S | |
18 | 54 | F | RFA | Colon | Meta | Yes | D | |
19 | 52 | F | RFA | Rectum | Meta | No | S | |
20 | 60 | M | RFA | Colon | Meta | Yes | D | |
21 | 55 | M | RFA | Rectum | Meta | Yes | D | |
22 | 75 | M | Resection | Colon | Syn | Yes | D | |
23 | 54 | F | RFA | Rectum | Meta | Yes | D | |
24 | 63 | F | RFA | Colon | Syn | Yes | D | |
25 | 66 | M | Resection | Rectum | Syn | Yes | S | |
26 | 56 | F | RFA | Rectum | Meta | Yes | D | |
27 | 67 | M | Resection | Colon | Meta | Yes | D | |
28 | 58 | M | RFA | Rectum | Syn | No | S | |
29 | 71 | M | Resection | Colon | Meta | Yes | S |
Table 3 Summary of pathological findings
No. | Metastatic tumor size (cm) | Diff | T | N | M | LNR | LV | PN |
1 | 2.5 | Mod | 3 | 2 | 0 | 0.23 | Pos | Pos |
2 | 1.6 | Mod | 3 | 2 | 0 | 0.17 | Pos | Pos |
3 | 4 | Mod | 4 | 2 | 0 | 0.37 | Pos | Pos |
4 | 4.2 | Mod | 4 | 1 | 0 | 0.43 | Pos | Pos |
5 | 3.2 | Mod | 3 | 1 | 1 | 0.07 | Pos | Neg |
6 | 4.2 | Mod | 2 | 2 | 0 | 0.25 | Pos | Pos |
7 | 4 | Mod | 3 | 0 | 1 | 0 | Pos | Pos |
8 | 2.8 | Mod | 4 | 0 | 0 | 0 | Pos | Pos |
9 | 4.4 | Mod | 1 | 2 | 0 | 0.06 | Neg | Neg |
10 | 4.9 | Well | 3 | 1 | 1 | 0.03 | Pos | Neg |
11 | 2.8 | Mod | 3 | 0 | 0 | 0 | Neg | Pos |
12 | 2.3 | Mod | 4 | 1 | 0 | 0.08 | Neg | Neg |
13 | 3.2 | Mod | 4 | 2 | 1 | 0.33 | Neg | Pos |
14 | 1.2 | Mod | 3 | 2 | 0 | 0.14 | Pos | Pos |
15 | 0.9 | Poor | 3 | 2 | 0 | 0.12 | Pos | Pos |
16 | 1.7 | Poor | 3 | 1 | 0 | 0.04 | Pos | Pos |
17 | 2 | Mod | 3 | 1 | 0 | 0.03 | Neg | Neg |
18 | 1 | Mod | 3 | 2 | 0 | 0.34 | Pos | Pos |
19 | 2.5 | Mod | 4 | 0 | 0 | 0 | Neg | Neg |
20 | 2 | Mod | 3 | 1 | 0 | 0.14 | Pos | Pos |
21 | 1.6 | Mod | 3 | 1 | 0 | 0.08 | Pos | Pos |
22 | 1 | Mod | 3 | 1 | 0 | 0.04 | Pos | Pos |
23 | 3.8 | Mod | 2 | 0 | 0 | 0 | Neg | Neg |
24 | 3.7 | Mod | 3 | 0 | 1 | 0 | Neg | Neg |
25 | 1 | Mod | 3 | 0 | 0 | 0 | Neg | Neg |
26 | 3.6 | Mod | 4 | 2 | 1 | 0.58 | Neg | Pos |
27 | 1.2 | Mod | 3 | 0 | 0 | 0 | Pos | Pos |
28 | 0.8 | Mod | 4 | 1 | 1 | 0.03 | Neg | Neg |
29 | 1.3 | Mod | 3 | 0 | 0 | 0 | Neg | Neg |
Table 4 Clinicopathological data of colorectal liver metastasis n (%)
RFA (n = 17) | Resection (n = 12) | P-value | ||
Sex | Male | 7 (41) | 4 (33) | 0.49 |
Female | 10 (59) | 8 (67) | ||
Age (yr) | 61.35 ± 8.33 | 67.50 ± 7.44 | 0.07 | |
Age (yr) | ≤ 65 | 12 (71) | 4 (33) | 0.07 |
> 65 | 5 (29) | 8 (67) | ||
Timing of metastasis | Synchronous | 5 (29) | 3 (25) | 1.00 |
Metachronous | 12 (71) | 9 (75) | ||
Primary site | Colon | 10 (59) | 8 (67) | 0.72 |
Rectum | 7 (41) | 4 (33) | ||
T stage | I-III | 13 (76) | 8 (67) | 0.68 |
IV | 4 (24) | 4 (33) | ||
Lymphovascular | Positive | 8 (47) | 8 (67) | 0.45 |
Invasion | Negative | 9 (53) | 4 (33) | |
Perineural invasion | Positive | 10 (59) | 7 (58) | 1.00 |
Negative | 7 (41) | 5 (42) | ||
Lymph node metastasis | Positive | 11 (65) | 9 (75) | 0.69 |
Negative | 6 (35) | 3 (25) | ||
Size of metastasis (cm) | 2.02 ± 1.17 | 3.59 ± 0.81 | 0.03 | |
Size of metastasis | ≤ 3 cm | 13 (76) | 5 (42) | 0.07 |
> 3 cm | 4 (24) | 7 (58) | ||
Recurrence | Yes | 14 (82) | 9 (75) | 0.67 |
No | 3 (18) | 3 (25) |
Table 5 Univariate analysis of 5-year overall survival
RFA (n = 17) | Resection (n = 12) | P-value | ||||
3-yr | 5-yr | 3-yr | 5-yr | |||
Sex | Female | 42.9% | 42.9% | 100% | 100% | 0.083% |
Male | 60.0% | 30.0% | 50.0% | 50.0% | 0.925% | |
Age (yr) | ≤ 65 | 58.3% | 38.9% | 50.0% | 50.0% | 0.848% |
> 65 | 40.0% | 40.0% | 75.0% | 75.0% | 0.187% | |
Primary | 1-3 | 50.0% | 33.3% | 75.0% | 75.0% | 0.194% |
T stage | 4 | 66.7% | 66.7% | 50.0% | 50.0% | 0.847% |
Timing of | Synchronous | 33.3% | 33.3% | 100% | 100% | 0.093% |
Metastasis | Metachronous | 63.6% | 42.4% | 55.6% | 55.6% | 0.975% |
Preoperative chemotherapy | No | 50.0% | 50.0 | 66.7 | 66.7 | 0.410 |
Yes | 54.5% | 36.4% | 66.7% | 66.7% | 0.495% | |
Primary site | Colon | 50.0% | 37.5% | 75.0% | 75.0% | 0.202% |
Rectum | 57.1% | 38.1% | 50.0% | 50.0% | 0.992% | |
Metastatic | Negative Positive | 50.0% | 50.0% | 100% | 100% | 0.175% |
Lymph node | 54.5% | 32.7% | 55.6% | 55.6% | 0.502% | |
Lymphovascular invasion | Negative | 55.6% | 55.6% | 100% | 100% | 0.140% |
Positive | 50.0% | 25.0% | 50.0% | 50.0% | 0.638% | |
Perineural invasion | Negative Positive | 71.4% | 71.4% | 100% | 100% | 0.214% |
40.0% | 20.0% | 42.9% | 42.9% | 0.515% | ||
Primary | ≤ 3 cm | 69.2% | 49.50% | 80.0% | 80.0% | 0.464% |
Tumor size | > 3 cm | 0.0% | 0.0% | 57.1% | 57.1% | 0.005% |
Postoperative chemotherapy | No | 20.0% | 20.0% | 0.0% | 0.0% | 0.929% |
Yes | 66.7% | 47.6% | 80.0% | 80.0% | 0.341% |
Table 6 Univariate analysis of 5-year disease-free survival
RFA (n = 17) | Resection (n = 12) | P-value | ||||
3-yr | 5-yr | 3-yr | 5-yr | |||
Sex | Female | 28.6% | 28.6% | 50.0% | 50.0% | 0.350 |
Male | 10.0% | 10.0% | 50.0% | 33.3% | 0.039 | |
Age (yr) | ≤ 65 | 25.0% | 25.0% | 50.0% | 25.0% | 0.449 |
> 65 | 0.0% | 0.0% | 46.9% | 46.9% | 0.012 | |
Primary | I-III | 7.1% | 7.1% | 50.0% | 25.0% | 0.023 |
T Stage | IV | 66.7% | 66.7% | 50.0% | 50.0% | 0.702 |
Timing of | Synchronous | 16.7% | 16.7% | 66.7% | 66.7% | 0.201 |
Metastasis | Metachronous | 18.2% | 18.2% | 41.7% | 20.8% | 0.172 |
Preoperative chemotherapy | No | 16.7% | 16.7% | 53.3% | 53.3% | 0.112 |
Yes | 18.2% | 18.2% | 33.3% | 0.0% | 0.617 | |
Primary site | Colon | 10.0% | 10.0% | 50.0% | 25.0% | 0.048 |
Rectum | 28.6% | 28.6% | 37.5% | 37.5% | 0.385 | |
Metastatic | Negative | 16.7% | 16.7% | 100.0% | 100.0% | 0.037 |
Lymph node | Positive | 18.2% | 18.2% | 29.6% | 14.8% | 0.325 |
Lymphovascular invasion | Negative | 22.2% | 22.2% | 50.0% | 50.0% | 0.137 |
Positive | 12.5% | 12.5% | 50.0% | 33.3% | 0.197 | |
Perineural invasion | Negative | 28.6% | 28.6% | 40.0% | 40.0% | 0.423 |
Positive | 10.0% | 10.0% | 57.1% | 28.6% | 0.074 | |
Primary | ≤ 3 cm | 23.1% | 23.1% | 60.0% | 30.0% | 0.204 |
Tumor size | > 3 cm | 0.0% | 0.0% | 38.1% | 38.1% | 0.013 |
Postoperative chemotherapy | No | 0.0% | 0.0% | 50.0% | 50.0% | 0.151 |
Yes | 25.0% | 25.0% | 50.0% | 33.3% | 0.235 |
- Citation: Ko S, Jo H, Yun S, Park E, Kim S, Seo HI. Comparative analysis of radiofrequency ablation and resection for resectable colorectal liver metastases. World J Gastroenterol 2014; 20(2): 525-531
- URL: https://www.wjgnet.com/1007-9327/full/v20/i2/525.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i2.525