miRNA polymorphisms and risk of gastric cancer in Asian population

Table 1 List miRNA-single-nucleotide polymorphisms evaluated in gastric cancer

First author year	Population	miRNA	SNP ID	Allele	Case/control	Risk1 (OR and 95%CI)
Peng et al[40] 2010	Chinese	miR-196a-2	rs11614913	T/C	213/213	1.57 (1.03-2.39)
Okubo et al[41] 2010	Japanese	miR-146a	rs2910164	G/C	552/697	1.30 (1.02-1.66)
		miR-196a-2	rs11614913	T/C	552/697	NS
		miR-499	rs3746444	A/G	552/697	NS
Sun et al[16] 2010	Chinese	miR-27a	rs895819	A/G	304/304	1.48 (1.06-2.05)
Zeng et al[17] 2010	Chinese	miR-146a	rs2910164	C/G	304/304	1.58 (1.11-2.20)
Hishida et al[56] 2011	Japanese	miR-146a	rs2910164	C/G	583/540	NS
Mu et al[42] 2012	Chinese	miR-30c	rs928508	A/G	240/240	1.83 (1.07-3.15)
Zhang et al[43] 2012	Chinese	miR-149	rs2292832	T/C	762/757	NS
		miR-605	rs2043556	A/G	762/757	NS
Arisawa et al[44] 2012	Japanese	miR-938	rs2505901	T/C	333/574	0.73 (0.55-0.99)
Ahn et al[50] 2012	South Korean	miR-146a	rs2910164	C/G	461/447	NS
		miR-149	rs2292832	T/C	461/447	NS
		miR-196a-2	rs11614913	T/C	461/447	NS
		miR-499	rs3746444	A/G	461/447	NS
Zhou et al[53] 2012	Chinese	miR-27a	rs895819	A/G	295/413	0.28 (0.12-0.66)
Yang et al[54] 2012	Chinese	miR-27a	rs11671784	G/A	892/978	0.76 (0.63–0.92)
		miR-27a	rs895819	A/G	892/978	NS
Zhou et al[57] 2012	Chinese	miR-146a	rs2910164	C/G	1686/1895	1.26 (1.01-1.56)
Wang et al[51] 2013	Chinese	miR-196a-2	rs11614913	T/C	1689/1946	0.71 (0.60-0.83)

¹Risk estimate by authors supplied main results in full text.

Table 2 miR-196a-2 single-nucleotide polymorphism (rs11614913) in gastric cancer

First author year	Study design	Case/control	Case			Control			Risk1 (OR and 95%CI)
			TT	CT	CC	TT	CT	CC
Peng et al[40] 2010	HB	213/213	43	94	76	50	107	56	1.56 (1.03-2.35)
Okubo et al[41] 2010	HB	552/697	166	281	105	223	350	124	1.09 (0.81-1.45)
Ahn et al[50] 2012	HB	461/447	119	242	100	128	232	87	1.15 (0.83-1.58)
Wang et al[51] 2013	HB	1689/1946	519	851	319	524	940	482	0.71 (0.60-0.83)
Overall		2915/3303	847	1468	600	925	1629	749	1.06 (0.74-1.50)

¹OR and 95%CI were calculated under a recessive genetic model (CC vs CT + TT). HB: Hospital based.

Table 3 MiR-27a single-nucleotide polymorphism ( rs895819) in gastric cancer

First author year	Study design	Case/control	Case			Control			Risk1 (OR and 95%CI)
			AA	AG	GG	AA	AG	GG
Sun et al[16] 2010	HB	304/304	115	135	54	145	119	40	1.50 (1.08-2.07)
Zhou et al[53] 2012	HB	295/413	166	122	7	214	167	32	0.84 (0.62-1.12)
Yang et al[54] 2012	HB	892/978	349	437	106	367	472	139	0.93 (0.76-1.13)
Overall		1491/1695	630	694	167	726	758	211	1.04 (0.76-1.42)

¹OR and 95%CI were calculated under a dominant genetic model (AG + GG vs AA). HB: Hospital based.

Table 4 MiR-146a single-nucleotide polymorphism ( rs2910164) in gastric cancer

First author year	Study design	Case/control	Case			Control			Risk1 (OR and 95%CI)
			CC	CG	GG	CC	CG	GG
Okubo et al[41] 2010	HB	552/697	236	243	73	254	322	121	0.73 (0.53-0.99)
Zeng et al[17] 2010	HB	304/304	89	153	62	119	132	53	1.21 (0.81-1.82)
Hishida et al[56] 2011	HB	583/540	230	271	82	215	254	71	1.08 (0.77-1.52)
Ahn et al[50] 2012	HB	461/447	159	231	71	164	221	62	1.13 (0.78-1.63)
Zhou et al[57] 2012	HB	1686/1895	286	822	578	393	951	551	1.27 (1.10-1.47)
Overall		3586/3913	1000	1720	866	1145	1880	858	1.08 (0.87-1.33)

¹OR and 95%CI were calculated under a recessive genetic model (GG vs CC + CG). HB: Hospital based.