Hua HB, Yan TT, Sun QM. miRNA polymorphisms and risk of gastric cancer in Asian population. World J Gastroenterol 2014; 20(19): 5700-5707 [PMID: 24914331 DOI: 10.3748/wjg.v20.i19.5700]
Corresponding Author of This Article
Qing-Min Sun, MD, Department of Pharmacy, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. qingminsun@gmail.com
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. May 21, 2014; 20(19): 5700-5707 Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5700
miRNA polymorphisms and risk of gastric cancer in Asian population
Hai-Bing Hua, Ting-Ting Yan, Qing-Min Sun
Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China
Ting-Ting Yan, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Qing-Min Sun, Department of Pharmacy, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Author contributions: Hua HB and Yan TT contributed equally to this work; Hua HB reviewed the literature and wrote the article; Yan TT contributed to the analysis and interpretation of the data; Sun QM designed the review and revised the article; all authors have read and approved the final version to be published.
Supported by National Natural Science Foundation of China, No. 81001444; Science and Technology Development Project of Nanjing, China, No. 201201055 and No. 2012YX001; and Natural Science Research in Colleges and Universities of Jiangsu Province, No. 11KJD360002
Correspondence to: Qing-Min Sun, MD, Department of Pharmacy, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. qingminsun@gmail.com
Telephone: +86-25-86619821 Fax: +86-25-86619821
Received: August 29, 2013 Revised: November 4, 2013 Accepted: January 3, 2014 Published online: May 21, 2014 Processing time: 261 Days and 21.2 Hours
Abstract
miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.
Core tip: Host genetic susceptibility plays an important role in gastric carcinogenesis. In this review, we summarize current knowledge about the functional effects of miRNA-single-nucleotide polymorphisms (SNPs) and their importance in gastric cancer susceptibility. Furthermore, we also conduct a simple meta-analysis about most frequently studied miRNA-SNPs (rs11614913 in miR-196a-2, rs895819 in miR-27a and rs2910164 in miR-146a) in gastric cancer.
