Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications

Table 1 Commensal enteric microbial protease classification and origin

Protease category	Microbial origin	Protease
Aspartic	Candida albicans	Secreted aspartic proteases[119]
	Pseudomonas aeruginosa	Type 4 prepilin peptidase[120]
	Methanococcus voltae	Preflagellin[121]
Cysteine	Gram positive bacteria	Sortases[122]
	Porphyromonas gingivalis	Gingipain[21]
	Staphylococcus aureus	Staphopain[123]
Metalloprotease	Bacteroides fragilis	Fragilysin[124]
	Enterococcus faecalis	Gelatinase[87]
	Staphylococcus epidermidis	Elastase[123]
	Clostridium perfringens	Collagenase[13]
Serine	Helicobacter pylori	High temperature requirement A[125]
	Bacillus subtilis	Subtilisin[126]