Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2013; 19(32): 5227-5237
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5227
Table 1 Intramural spreading distance after neoadjuvant therapy
Ref.No. of patientsNeoadjuvant therapy regimen
Intramural spreading distance
Radiotherapy (Gy)Chemotherapy0-5 mm6-10 mm>10 mm
Chmielik et al[32]1065 × 5None9394
Chmielik et al[32]8650.45-Fu + LV7880
Mezhir et al[37]2050.45-Fu + LV1271
Guillem et al[36]10950.45-Fu + LV10810
Table 2 Association between ypT stage and ypN status n (%)
Ref.No. of patientsNeoadjuvant therapy regimen
Time interval1 (wk)No. of patients with ypT0/T1
Radiotherapy (Gy)ChemotherapyypN+/ypT0-1ypN+/ypT2-4
Zmora et al[42]10945-50.45-Fu64/33 (12.1)30/61 (49.2)
Read et al[43]64420-455-FuNS3/87 (3.4)217/557 (39.0)
Bujko et al[44]1475 × 510/4 (0.0)69/138 (50.0)
Bujko et al[44]13850.45-Fu4-62/33 (6.1)41/101 (40.6)
Pucciarelli et al[45]23545-50.45-Fu6-83/69 (4.3)45/166 (27.1)
Tulchinsky et al[46]101455-Fu5-71/22 (4.5)29/75 (38.7)
Habr-Gama et al[47]40150.45-Fu83/25 (10.7)75/224 (33.5)
Stipa et al[48]18750.45-FuNS3/44 (6.8)48/143 (33.6)
Kundel et al[49]320455-Fu4-83/69 (4.3)49/222 (22.1)
Gavioli et al[31]139505-Fu42/34 (5.9)38/105 (36.2)
Kim et al[50]282455-Fu4-82/58 (3.4)85/224 (37.9)
Lindebjerg et al[51]135605-Fu88/47 (17.0)32/88 (36.4)
Coco et al[52]271NSNSNS3/71 (4.2)70/200 (35.0)
Total310937/596 (6.2)828/2304 (35.9)
Table 3 Relationship between tumor response and local recurrence rate n (%)
Ref.No. of patientsNeoadjuvant therapy regimen
No. of LR
Radiotherapy (Gy)ChemotherapypCR LR/totalNon-pCR LR/total
Gavioli et al[31]139505-Fu0/25 (0.0)8/114 (7.0)
Stipa et al[57]200505-Fu0/60 (0.0)6/140 (4.3)
Hughes et al[71]130455-Fu0/23 (0.0)23/107 (17.7)
Kim et al[82]11450.45-Fu0/10 (0.0)17/104 (16.3)
Kuo et al[83]248505-Fu2/36 (5.6)66/212 (31.1)
Chan et al[84]128505-Fu0/32 (0.0)24/96 (18.4)
García-Aguilar et al[86]16840-655-Fu0/21 (0.0)7/147 (5)
Wheeler et al[87]6345-505-Fu1/29 (3.4)8/34 (23.5)
Theodoropoulos et al[88]88455-Fu0/16 (0.0)3/72 (4.2)
Total12783/252 (1.2)162/1026 (15.8)