Tumor necrosis factor-&alpha; mediates JNK activation response to intestinal ischemia-reperfusion injury

doi:10.3748/wjg.v19.i30.4925

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2013; 19(30): 4925-4934
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4925

Table 1 Inhibition of tumor necrosis factor reduced mucosal injured scoring after intestinal ischemia-reperfusion

Group	Mucosal injured scoring
Group	Jejunum	Ileum
SO rats: pretreated with vehicle	0.0 (0-1)	0.0 (0-1)
I/R rats: pretreated with vehicle	5.0 (4-5)^a	4.5 (4-5)^a
I/R rats: pretreated with PTX	3.0 (2-4)^a^c	3.0 (2-4)^a^c
I/R rats: pretreated with IFX	3.5 (2-4)^a^c	3.0 (2-4)^a^c

Values are expressed as the median (range). Six rats were tested in each group.

^aP < 0.05 vs sham-operated (SO) rats pretreated with vehicle,

^cP < 0.05 vs ischemia-reperfusion (I/R) rats pretreated with vehicle. PTX: Pentoxifylline; IFX: Infliximab.

Citation: Yang Q, Zheng FP, Zhan YS, Tao J, Tan SW, Liu HL, Wu B. Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury. World J Gastroenterol 2013; 19(30): 4925-4934
URL: https://www.wjgnet.com/1007-9327/full/v19/i30/4925.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i30.4925