Azathioprine-induced fever in autoimmune hepatitis

Table 1 Revised international autoimmune hepatitis group scoring system for the diagnosis of autoimmune hepatitis

Clinical feature	Score	Patient
Female gender	+2	+2
ALP:AST ratio		+2
< 1.5	+2
1.5-3.0	0
> 3.0	-2
Serum globulin or IgG above normal		+2
> 2.0	+3
1.5-2.0	+2
1.0-1.5	+1
< 1.0	0
ANA, SMA, LKM1		+3
> 1:80	+3
1:80	+2
1:40	+1
< 1:40	0
Illicit drug use history		+1
Positive	-4
Negative	+1
Average alcohol intake daily		+2
< 25 g/d	+2
> 60 g/d	-2
Histologic findings		Lymphoplasmacytic infiltrate
Interface hepatitis	+3	+1
Lymphoplasmacytic infiltrate	+1
Rosette formation	+1
None of the above	-5
Biliary changes	-3
Other changes	+2
Other autoimmune disease	+2	No other autoimmune disease
AMA positivity	-4	AMA negative
Hepatitis viral markers		+3
Positive	-3
Negative	+3
Aggregate score without treatment		Overall 16 points
Definite AIH	> 15
Probable AIH	10-15

ALP: Alkaline phosphatase; AST: Aspertate aminotransferase; AIH: Autoimmune hepatitis; ANA: Anti-nuclear antibody; SMA: Soluble ribonucleic acid; LKM: Liver-kidney microsomal; IgG: Immunoglobulin G.