BPG is committed to discovery and dissemination of knowledge
Home / Archive / Volume 19, Issue 20
  • This Article
Citation of this article
Corresponding Author of This Article
Research Domain of This Article
Article-Type of This Article
Open-Access Policy of This Article
Times Cited Counts in Google of This Article
Number of Hits and Downloads for This Article
  • Total Article Views (10646)
All Articles published online
The chart showing PDF series, HTML series, Tables (1-6) series.
Item 
Count 
PDF2672
HTML5056
Tables (1-6)462
 Sum=8190
Publishing Process of This Article
The chart showing Browse series, Download series.
Item 
Count 
Browse1221
Download1235
 Sum=2456
May 28, 2013 (publication date) through Oct 22, 2025
Times Cited of This Article
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. May 28, 2013; 19(20): 3096-3107
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3096
Table 1 Demographics of 202 patients with early gastric cancer
Patients (n = 202)
Age
< 60 yr109
≥ 60 yr93
Sex
Male132
Female70
Tumor site
Upper25
Middle98
Lower79
Size of tumor
≤ 2 cm97
> 2 cm105
No. of resected nodes
< 15114
≥ 1588
Tumor depth
Mucosal122
Submucosal80
Macroscopic type
Elevated25
Flat21
Depressed156
Histologic type
Differentiated121
Undifferentiated81
Lyphovessel ambolus
+2
-200
Vessel ambolus
+5
-197
Nerve invasion
+0
-202
CEA
+1
-201
CEA: Carcinoembryonic antigen.
Full Size Table
Table 2 Univariate analysis of lymph node metastases in early gastric cancer and clinicopathological factors n (%)
Clinicopathological factorsLN (+)LN (-)P1
The entire study population
Age0.887
< 60 yr16 (14.7)93 (85.3)
≥ 60 yr13 (14.0)80 (86.0)
Sex0.213
Male16 (12.1)116 (87.9)
Female13 (18.6)57 (81.4)
Tumor site0.001
Upper2 (8.0)23 (92.0)
Middle15 (15.3)83 (84.7)
Lower12 (15.2)67 (84.8)
Size of tumor0.240
≤ 2 cm11 (11.3)86 (88.7)
> 2 cm18 (17.1)87 (82.9)
No. of resected nodes0.580
< 1515 (13.2)99 (86.9)
≥ 1514 (15.9)74 (84.1)
Tumor depth0.008a
Mucosal11 (9.0)111 (91.0)
Submucosal18 (22.5)62 (77.5)
Macroscopic type0.001a
Elevated4 (16)21 (84)
Flat3 (14.3)18 (85.7)
Depressed22 (14.1)134 (85.9)
Histologic type0.332
Differentiated15 (12.4)106 (87.6)
Undifferentiated14 (17.3)67 (82.7)
Lyphovessel ambolus0.149
+1 (50.0)1 (50.0)
-28 (14.0)172 (86.0)
Vessel ambolus0.003a
+3 (60.0)2 (40.0)
-26 (13.2)171 (86.8)
Nerve invasionN
+0 (0)0 (0)
-29 (14.4)173 (85.6)
CEA0.681
+0 (0)1 (100)
-29 (14.4)173 (85.6)
Mucosa cancer
Age0.234
< 60 yr8 (11.8)60 (88.2)
≥ 60 yr3 (5.6)51 (94.4)
Sex0.578
Male6 (7.9)70 (92.1)
Female5 (10.9)41 (89.1)
Tumor site0.976
Upper1 (10.0)9 (90.0)
Middle6 (9.4)58 (90.6)
Lower4 (8.3)44 (91.7)
Size of tumor0.142
≤ 2 cm3 (5.1)56 (94.9)
> 2 cm8 (12.7)55 (87.3)
No. of resected nodes0.580
< 157 (10.3)61 (89.7)
≥ 154 (7.4)50 (92.6)
Macroscopic type0.539
Elevated2 (11.1)16 (88.9)
Flat0 (0)11 (100)
Depressed9 (9.7)84 (90.3)
Histologic type0.073
Differentiated4 (5.3)71 (94.7)
Undifferentiated7 (14.9)40 (85.1)
Lyphovessel ambolusN
+0 (0)0 (0)
-11 (9.0)111 (91.0)
Vessel ambolusN
+0 (0)0 (0)
-11 (9.0)111 (91.0)
Nerve invasionN
+0 (0)0 (0)
-11 (9.0)110 (91.0)
CEA0.752
+0 (0)1 (100)
-11 (9.1)110 (90.9)
Submucosal cancer
Age0.512
< 60 yr8 (19.5)33 (80.5)
≥ 60 yr10 (25.6)29 (74.4)
Sex0.129
Male10 (17.9)46 (82.1)
Female8 (33.3)16 (66.7)
Tumor site0.265
Upper1 (6.7)14 (93.3)
Middle9 (26.5)25 (73.5)
Lower8 (25.8)23 (74.2)
Tumor size0.768
≤ 2 cm8 (21.1)30 (78.9)
> 2 cm10 (23.8)32 (76.2)
No. of resected nodes0.203
< 158 (17.4)38 (82.6)
≥ 1510 (29.4)24 (70.6)
Macroscopic type0.742
Elevated2 (28.6)5 (71.4)
Flat3 (30.0)7 (70.0)
Depressed13 (20.6)50 (79.4)
Histologic type0.725
Differentiated11 (23.9)35 (76.1)
Undifferentiated7 (20.6)27 (79.4)
Lyphovessel ambolus0.346
+1 (50.0)1 (50.0)
-17 (21.8)61 (78.2)
Vessel ambolus0.038a
+3 (60.0)2 (40.0)
-15 (20.0)60 (80.0)
Nerve invasionN
+0 (0)0 (0)
-18 (22.5)62 (77.5)
CEAN
+0 (0)0 (0)
-18 (22.5)62 (77.5)
1Statistically significant. Tumor site: middle and lower vs upper; Tumor depth: submucosa vs mucosa; Macroscopic type: flat and depressed vs elevated; Vessel ambolus: + (present) vs - (absent),
aP < 0.05. In patients with mucosal cancers, no significant differences in the occurrence of lymph node metastases were found in relation to the clinicopathological factors. CEA: Carcinoembryonic antigen.
Full Size Table
Table 3 Multivariate analysis of lymph node metastases in early gastric cancer for the entire study population
RR95%CIP1
Tumor site1.1590.84-1.4780.644
Invasion depth2.7442.316-3.1720.018a
Macroscopic type0.8640.57-1.1580.620
Vessel amblous4.1473.242-5.0520.116
Constant term0.037-2.5680.010
1Statistically significant, invasion depth: submucosa vs mucosa,
aP < 0.05.
Full Size Table
Table 4 Number of retrieved lymph nodes and lymph node metastasis ratios for involved lymph nodes at each nodal station in early gastric cancer
Node groupNo. of dissected nodesNo. of metastasis nodesIncidence of lymphnode metastasis (%)
No. 116510.6
No. 227311.1
No. 3861414.8
No. 4670233.4
No. 57822.6
No. 6358215.9
No. 726341.5
No. 812032.5
No. 913432.2
No. 101600.0
No. 112713.7
No. 1210800.0
No. 135800.0
No. 1423834.8
No. 151300.0
No. 16500.0
Total29261103.8
Full Size Table
Table 5 Lymph node metastasis ratios and incidence at each station in upper third, middle third and lower third gastric cancers
Node groupUpper
Middle
Lower
pN categoryIncidenceRatiopN categoryIncidenceRatiopN categoryIncidenceRatio
No. 1pN10.0 (0/52)0.0 (0/25)pN17.4 (1/73)1.0 (1/98)pN20.0 (0/40)0.0 (0/79)
No. 2pN15.3 (1/19)4.0 (1/25)pN328.6 (2/7)1.0 (1/98)M0.0 (0/1)0.0 (0/79)
No. 3pN15.5 (7/128)8.0 (2/25)pN13.8 (17/445)9.2 (9/98)pN15.9 (17/288)8.9 (7/79)
No. 4pN11.6 (1/62)4.0 (1/25)pN14.3 (15/347)5.1 (5/98)pN12.7 (7/261)6.3 (5/79)
No. 5pN30.0 (0/6)0.0 (0/25)pN12.6 (1/38)1.0 (1/98)pN12.9 (1/34)1.3 (1/79)
No. 6pN30.0 (0/21)0.0 (0/25)pN12.2 (4/182)2.0 (2/98)pN111.0 (17/155)8.9 (7/79)
No. 7pN20.0 (0/21)0.0 (0/25)pN20.0 (0/141)0.0 (0/98)pN24.0 (4/101)1.3 (1/79)
No. 8pN216.7 (2/12)4.0 (1/25)pN21.6 (1/63)1.0 (1/98)pN20.0 (4/45)0.0 (0/79)
No. 9pN20.0 (0/5)0.0 (0/25)pN23.5 (3/85)3.1 (3/98)pN20.0 (4/44)0.0 (0/79)
No. 10pN20.0 (0/2)0.0 (0/25)pN30.0 (0/3)0.0 (0/98)M0.0 (0/11)0.0 (0/79)
No. 11pN20.0 (0/4)0.0 (0/25)pN27.1 (1/14)1.0 (1/98)pN20.0 (0/9)0.0 (0/79)
No. 12pN30.0 (0/6)0.0 (0/25)pN20.0 (0/61)0.0 (0/98)pN20.0 (0/41)0.0 (0/79)
No. 13M0.0 (0/10)0.0 (0/25)pN30.0 (0/31)0.0 (0/98)pN30.0 (0/17)0.0 (0/79)
No. 14M0.0 (0/2)0.0 (0/25)pN341.2 (7/17)1.0 (1/98)pN225.0 (1/4)1.3 (1/79)
No. 15M0.0 (0/1)0.0 (0/25)M0.0 (0/9)0.0 (0/98)M0.0 (0/3)0.0 (0/79)
No. 16M0.0 (0/0)0.0 (0/25)pN30.0 (0/5)0.0 (0/98)pN30.0 (0/0)0.0 (0/79)
Full Size Table
Table 6 Correlation between lymph node metastases at pN1 and pN2 and clinicopathological factors
pN1
pN2
-+P-+P
Tumor size (cm)0.240.295
≤ 2.086 (88.7)11 (11.3)95 (97.9)2 (2.1)
> 2.087 (82.9)18 (17.1)100 (95.2)5 (4.8)
Macroscopic type0.9690.259
Elevated21 (84.0)4 (16.0)24 (96.0)1 (4.0)
Flat18 (85.7)3 (14.3)19 (90.5)2 (9.5)
Depressed134 (85.9)22 (14.1)152 (97.4)4 (2.6)
Invasion depth0.0080.334
Mucosal111 (91.0)11 (9.0)119 (97.5)3 (2.5)
Submucosal62 (77.5)18 (22.5)76 (95.0)4 (5.0)
Differentiate0.3320.349
Differentiated106 (87.6)15 (12.4)118 (97.5)3 (2.5)
Undifferentiated67 (82.7)14 (17.3)77 (95.1)4 (4.9)
Lymphovascular invasion0.1260.804
No174 (87.0)26 (13.0)194 (97.0)6 (3.0)
Yes1 (50.0)1 (50.0)2 (100.0)0 (0.0)
Full Size Table
Write to the Help Desk
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

California Corporate Number: 3537345