A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population

Table 1 Demographic characteristics of the hepatocellular carcinoma case and control groups

Characteristics	Case		Control		P value
	n = 270	Frequency (%)	n = 270	Frequency (%)
Age, (yr) (mean ± SD)	50.3 ± 9.2		50.7 ± 9.4		0.91a
Gender
Male	187	69.3	190	70.4	0.78b
Female	83	30.7	80	29.6
Smoking status
Smoker	79	29.3	85	31.5	0.57b
Non-smoker	191	70.7	185	68.5
Drinking status
Drinker	120	44.4	116	43.0	0.73b
Non-drinker	150	55.6	154	57.0
Tumor stages
Ia + Ib	193	71.5
IIa + IIb	58	21.5
IIIa + IIIb	19	7.0
HBsAg, n (%)
Positive	201	74.4	26	9.6	< 0.0001b
Negative	69	25.6	244	90.4

^aTwo-sided two-sample t-tests.

^bχ² tests. HBsAg: Hepatitis B surface antigen.

Table 2 Genotype and allele frequencies of rs6147150 among cases and controls, and risk of hepatocellular carcinoma n (%)

Genotype/allele	Cases		Controls		OR (95% CI)1	P value
12N ins/ins	109	40.4	143	53.0	1.00 (Reference)	-
12N ins/del	117	43.3	104	38.5	1.48 (1.03-2.17)	0.034
12N del/del	44	16.3	23	8.5	2.50 (1.37-4.56)	0.001
Ptrend						0.0006
12N ins	335	62.0	390	72.2	1.00 (Reference)	-
12N del	205	38.0	150	27.8	1.59 (1.22-2.07)	0.0003

¹adjusted for sex, age, smoking status, drinking status, HBV infection and tumor stage. HBV: Hepatitis B virus; OR: Odds ratio; CI: Confidence interval.

Table 3 Stratification analysis based on hepatitis B virus infection status in cases and controls

Genotype	HBV positive					HBV negative
	Case	%	Control	%	OR1 (95% CI)	Case	%	Control	%	OR1 (95% CI)
12N ins/ins	82	40.8	14	53.8	1.00 (Reference)	28	40.6	127	52.0	1.00 (Reference)
12N ins/del	88	43.8	10	38.5	1.51(0.57-3.91)	30	43.5	90	36.9	1.52 (0.79-2.94)
12N del/del	31	15.4	2	7.7	2.64 (0.51-17.59)	11	15.9	27	11.1	1.87 (0.74-4.54)
Ptrend					P = 0.156					P = 0.083

¹Adjusted for sex, age, smoking status, drinking status and tumor stage. HBV: Hepatitis B virus; OR: Odds ratio; CI: Confidence interval.