Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis

Table 1 General status of gastric cancer patients and controls

Variables	Patients (n = 332) (%)	Controls (n = 380) (%)	P value
Age (yr)
mean ± SE	57.37 ± 0.68	56.92 ± 0.66	0.638
Gender
Male	208 (62.7)	194 (51.1)	0.002
Female	124 (37.3)	185 (48.9)
Helicobacter pylori infection
Yes	138 (41.6)	156 (41.1)	0.89
No	194 (58.4)	224 (58.9)
Tobacco smoking
Yes	86 (25.9)	82 (21.6)	0.175
No	246 (74.1)	298 (78.4)
Alcohol consumption
Yes	63 (19.0)	73 (19.2)	0.937
No	269 (81.0)	307 (80.8)

Table 2 Genotype and allele distribution of ICAM-1 +469 A/G polymorphism

	Patients(n = 332) (%)	Controls(n = 380) (%)	P valuea
Genotype
AA	190 (57.2)	187 (49.2)	0.032b
AG	116 (34.9)	169 (42.4)
GG	26 (7.8)	24 (8.4)
Allele
A	496 (74.7)	543 (71.4)	0.070
G	168 (25.3)	217 (28.6)

a: Pearson χ² test; b: AA vs AG + GG. ICAM-1: Intercellular adhesion molecule-1.

Table 3 Association between ICAM-1 +469 A/G polymorphism and clinicopathological parameters of patients with gastric cancer

Variables	Total	ICAM-1 +469 A/G genotype		P value
	(n = 332)	AA(n = 190) (%)	AG + GG(n = 142) (%)
Age (yr)				0.733
mean ± SE		57.17 ± 0.94	57.64 ± 0.99
Gender				0.355
Male	208	115 (60.5)	93 (65.5)
Female	124	75 (39.5)	49 (34.5)
Tumor size				0.154
≤ 5cm	174	106 (55.8)	68 (47.9)
> 5cm	158	84 (44.2)	74 (52.1)
Differentiation				0.760
Well	120	70 (36.8)	50 (35.2)
Poor	212	120 (63.2)	92 (34.8)
Lymph node metastasis				0.928
Negative	102	58 (30.5)	44 (31.0)
Positive	230	132 (69.5)	98 (69.0)
Vascular invasion				0.408
Negative	176	97 (51.1)	79 (55.6)
Positive	156	93 (48.9)	63 (44.4)
Distant metastasis				0.002
Negative	286	154 (81.1)	132 (93.0)
Positive	46	36 (18.9)	10 (7.0)
TNM stages				0.046a
I	62	35 (18.4)	27 (19.0)
II	60	35 (18.4)	25 (17.6)
III	134	68 (35.8)	66 (46.5)
IV	76	52 (27.4)	24 (16.9)

a: IV vs I + II + III. ICAM-1: Intercellular adhesion molecule-1.

Table 4 ICAM-1 +469 A/G polymorphism and sICAM-1 and ICAM-1 expression in gastric cancer

Characteristics	Total	Genotype		P value
	(n = 102)	AA	AG + GG
Serum sICAM-1				0.990
mean ± SE		176.00 ± 7.72	175.85 ± 9.40
ICAM-1 expression				0.197
Positive	29	13 (44.8)	16 (55.2)
Negative	73	43 (58.9)	30 (41.1)

ICAM-1: Intercellular adhesion molecule-1; sICAM-1: The soluble form of ICAM-1.