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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2012; 18(39): 5570-5575
Published online Oct 21, 2012. doi: 10.3748/wjg.v18.i39.5570
Published online Oct 21, 2012. doi: 10.3748/wjg.v18.i39.5570
Table 1 Baseline characteristics of the patients with hepatitis B virus genotype C
HBeAg-negative group | HBeAg-positive group | P value | |
No. | 26 | 24 | NS |
Age (yr) | 57.2 (35-80) | 44.2 (35-71) | < 0.01 |
Gender, M:F | 15:16 | 16:11 | NS |
Diseases, CH:LC/HCC | 21:5 | 23:1 | NS |
ALT (IU/mL) | 38 (13-950) | 102 (812-602) | < 0.01 |
Platelet counts (× 104/mL) | 18.6 (3.4-4.9) | 18.0 (8.4-26.8) | NS |
Albumin (mg/dL) | 4.3 (3.4-4.9) | 4.2 (2.3-5.0) | NS |
Serum HBV DNA level | 5.1 (3.9-8.8) | 7.6 (5.6-8.8) | < 0.01 |
(log copies/mL) |
Table 2 Clinical and virological results among the hepatitis B e antigen-negative group, the rapid-responders, and the slow-responders in the hepatitis B e antigen-positive group during 2 years of entecavir therapy
Characteristics | HBeAg-negative group | HBeAg-positive group | P value | |
(n = 26) | RR (n = 14) | SR (n = 10) | RR vs SR | |
<Baseline data> | ||||
Age | 58 (35-80) | 45 (34-68) | 43 (31-71) | NS |
Gender (male:female) | 13:13 | 9:5 | 6:4 | NS |
Disease (CH:LC/HCC) | 21:5 | 13:1 | 6:4 | NS |
ALT (IU/L) | 38 (13-950) | 131 (12-602) | 31 (13-108) | 0.02 |
Platelet count (× 104/mL) | 18.6 (3.4-35.1) | 17.1 (8.4-22.4) | 20.0 (11.0-26.8) | NS |
Albumin (mg/dL) | 4.3 (3.4-4.9) | 4.0 (2.3-5.0) | 4.4 (3.7-4.6) | NS |
HBV genotype C | 100% | 100% | 100% | NS |
HBV DNA (log copies/mL) | 5.1 (3.9-8.8) | 7.4 (5.6-8.8) | 8.3 (7.1-8.8) | NS |
qHBsAg (log IU/mL) | 3.17 (0.70-4.58) | 3.63 (1.68-4.34) | 4.57 (4.35-4.76) | < 0.01 |
HBcrAg (log U/mL) | 3.6 (3.0-> 6.8) | > 6.8 (6-> 6.8) | > 6.8 (> 6.8-> 6.8) | NS |
Pre-C mutation (%) | 83.3 | 0 | 0 | NS |
Core promoter mutation (%) | 58.3 | 57.1 | 50.0 | NS |
<At year 2 during therapy> | ||||
HBV DNA (log copies/mL) | 0.0 (0.0-2.7) | 2.1 (0.0-2.1) | 3.5 (3.1-6.9) | - |
ALT (IU/L) | 18 (9-75) | 17.5 (10-31) | 23 (13-37) | NS |
HBeAg seroconversion | - | 23.50% | 0% | NS |
HBsAg seroclearance | 0% | 0% | 0% | NS |
qHBsAg (log IU/mL) | 2.91 (0.62-3.9) | 3.25 (1.70-3.92) | 4.12 (3.23-4.47) | 0.01 |
HBcrAg (log U/mL) | 3.0 (3.0-5.4) | 5.9 (4.0-> 6.8) | > 6.8 (5.2-> 6.8) | < 0.01 |
Resistant mutations against entecavir | UDL | UDL | 0% | - |
Table 3 Drug resistant mutations in the slow-responders at year 2
Patient | Age (yr) | Gender | Previous therapy | HBV genotype | Drug resistant mutations against | ||||||
Lam | Lam | Lam/Ade | Ade | Ent | Ent | Ent | |||||
L180 | M204 | A181 | N236 | T184 | S202 | M205 | |||||
1 | 52 | Male | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
2 | 35 | Male | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
3 | 68 | Male | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
4 | 56 | Female | No | C | Wild | M204I | Wild | Wild | Wild | Wild | Wild |
5 | 36 | Female | No | C | Wild | M204I | Wild | Wild | Wild | Wild | Wild |
6 | 45 | Male | No | C | Wild | M204I | Wild | Wild | Wild | Wild | Wild |
7 | 35 | Male | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
8 | 67 | Female | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
9 | 39 | Male | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
10 | 44 | Female | No | C | Wild | Wild | Wild | Wild | Wild | Wild | Wild |
Table 4 Pretreatment clinical and virological characteristics between hepatitis B virus DNA-negative and -positive group at year 2 during entecavir therapy
Characteristics | HBV DNA-negative group | HBV DNA-positive group | P value | |
(n = 19) | (n = 31) | Univariate analysis | Multivariate analysis | |
Age | 51 (31-73) | 52 (32-80) | NS | |
Gender (male:female) | 12:7 | 20:11 | NS | |
Disease (CH:LC/HCC) | 17:2 | 27:4 | NS | |
ALT (IU/L) | 36 (12-366) | 108 (13-602) | 0.03 | NS |
Platelet counts (× 104/mL) | 19.0 (8.8-35.1) | 17.8 (3.4-26.8) | NS | |
Albumin (mg/dL) | 4.35 (3.84-4.85) | 4.14 (2.28-4.72) | NS | |
HBV genotype (B:C:others) | 0:19:0 | 0:31: | NS | |
HBeAg status (positive:negative) | 3:16 | 21:10 | < 0.01 | NS |
HBV DNA (log copies/mL) | 5.1 (3.1-7.4) | 7.6 (3.7-8.8) | < 0.01 | NS |
qHBsAg level (log IU/mL) | 3.31 (1.90-4.08) | 4.20 (3.06-4.87) | < 0.01 | 0.03 |
HBcrAg level (log U/mL) | 3.45 (3.0-> 6.8) | > 6.8 (3.0-> 6.8) | NS | |
Pre-C mutation (%) | 75.0 | 43.3 | NS | |
Core promoter mutation (%) | 37.5 | 60.0 | NS |
- Citation: Orito E, Fujiwara K, Kanie H, Ban T, Yamada T, Hayashi K. Quantitation of HBsAg predicts response to entecavir therapy in HBV genotype C patients. World J Gastroenterol 2012; 18(39): 5570-5575
- URL: https://www.wjgnet.com/1007-9327/full/v18/i39/5570.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i39.5570