Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study

Table 1 Greatest fold plasma microRNA changes in lethally dosed acetaminophen mice

MicroRNA	Fold increase	MicroRNA	Fold decrease
574-5p	203.7	342-3p	0.0005
135a*	173.6	195	0.0041
466g	110.7	375	0.0085
1196	82.7	29c	0.0134
466f-3p	71	148a	0.0152
877	64.4	652	0.0199
139-3p	59.7	202-5p	0.0317
686	48.8	200a	0.039
346	47.5	320	0.0422
149	34.9	374*	0.0508
485	34.5	9*	0.0556
409-3p	30.7	342-5p	0.0629
202-3p	28.1	192	0.0656
298	27.4	412	0.0713
15a	27.1	1	0.0775
341	26.2	199b	0.0775
296-3p	24.3	741	0.0902
466i	22.1	100	0.1145
1186	21.4	18b	0.1604
200a	20.5	122	0.2348

Table 2 Lethal acetaminophen associated plasma microRNAs and potential correlative function

MicroRNA	Function
574-5p	Acute and chronic asthma (Garbacki et al[23]); Procollagen type III A1 (Sterling[18])
135a	Hypoxia-inducible factor-1 and nuclear factor-κB production (Gonsalves et al[15])
466g	Acute and chronic asthma (Garbacki et al[23])
1196	Follicle-stimulating hormone regulation (Yao et al[16])
466f-3p	Acute and chronic asthma (Garbacki et al[23]); Procollagen type III A1 (Sterling[18])
877	Human type 1 diabetes (Zhou et al[17])
139-3p	Colon and rectal cancer (Slattery et al[19])
342-3p	HBV infection and HBV-positive hepatocarcinoma biomarker (Li et al[10])
195	E2F tumor suppressor (Xu et al[21])
375	Acute and chronic asthma (Garbacki et al[23]); Pyruvate dehydrogenase kinase inhibition in gastric carcinomas (Tsukamoto et al[20])
29c	Acute and chronic asthma (Garbacki et al[23])
148a	HLA-G and risk asthma (Tan et al[22])

HBV: Hepatitis B virus; E2F: Elongation factor 2; HLA-G: Human leukocyte antigen-G.