CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer

Table 1 Correlation of migration inhibitory factor, CD74 and toll-like receptor 4 expression with clinicopathological variables in gastric cancer n (%)

Variables	No.	CD74 expression		P	MIF expression		P	TLR4 expression		P
	Cases	Positive	Negative		Positive	Negative		Positive	Negative
Age (yr)				0.5959			0.8612			0.6421
< 60	46	40 (87)	6 (13)		38 (83)	8 (17)		38 (83)	8 (17)
> 60	74	60 (81)	14 (19)		59 (80)	15 (20)		61 (82)	13 (18)
Sex				0.9910			0.5817			0.6358
Male	75	61 (81)	14 (19)		60 (80)	15 (20)		60 (80)	15 (20)
Female	45	39 (87)	6 (13)		37 (82)	8 (18)		39 (87)	6 (13)
Histological type				0.3565			0.8440			0.2172
Well	20	16 (80)	4 (20)		16 (80)	4 (20)		17 (85)	3 (15)
Moderate	40	30 (75)	10 (25)		33 (83)	7 (17)		30 (75)	10 (25)
Poor	60	54 (90)	6 (10)		48 (80)	12 (20)		52 (87)	18 (13)
TNM stage				0.0141			0.0281			0.0153
I	26	16 (62)	10 (38)		17 (65)	9 (35)		17 (50)	9 (50)
II	28	20 (71)	8 (29)		22 (79)	6 (21)		20 (57)	8 (43)
III	33	29 (88)	4 (12)		28 (85)	5 (15)		30 (67)	3 (33)
IV	33	31 (94)	2 (6)		30 (91)	3 (19)		32 (85)	1 (15)
Lymph node metastasis				0.0158			0.0251			0.0152
Negative	50	37 (74)	13 (26)		36 (72)	14 (28)		33 (66)	17 (34)
Positive	70	63 (90)	7 (10)		61 (87)	9 (13)		66 (94)	4 (6)

MIF: Migration inhibitory factor; TLR4: Toll-like receptor 4.

Table 2 Correlation analysis of CD74, migration inhibitory factor and toll-like receptor 4 epithelial staining in 120 human gastric cancer patients

	MIF expression			r	P		TLR4 expression			r	P		TLR4 expression			r	P
CD74	(+)	(-)	Total	0.2367	< 0.01	CD74	(+)	(-)	Total	0.4414	< 0.01	MIF	(+)	(-)	Total	0.5501	< 0.01
(+)	85	15	100			(+)	90	10	100			(+)	89	8	97
(-)	12	8	20			(-)	9	11	20			(-)	10	13	23
Total	97	23	120			Total	99	21	120			Total	99	21	120

MIF: Migration inhibitory factor; TLR4: Toll-like receptor 4.