High-dose infliximab for treatment of pediatric ulcerative colitis: A survey of clinical practice

Table 1 Indication for initiation of infliximab 10 mg/kg

Answer options	Percentage (n)
Steroid refractory UC	70.5 (55)
Severe UC for maintenance of remission	64.1 (50)
Moderate-to-severe UC for maintenance of remission	62.8 (49)
Severe UC for induction of remission	55.1 (43)
Moderate-to-severe UC for induction of remission	38.5 (30)
Mild-to-moderate UC for maintenance of remission	9.0 (7)
Mild-to-moderate UC for induction of remission	2.6 (2)
Other	6.4 (5)

78 respondents. UC: Ulcerative colitis.

Table 2 Therapies introduced prior to infliximab 10 mg/kg

Answer options	Percentage (n)
Corticosteroids	96.2 (75)
Infliximab 5 mg/kg	92.3 (72)
Aminosalicylates	89.7 (70)
Azathioprine1	76.9 (60)
6-mercaptopurine1	70.5 (55)
Methotrexate	25.6 (20)
Other	14.1 (11)
None	1.3 (1)

¹Reported use by physicians included either azathioprine or 6-mercaptopurine in different patients. 78 respondents.

Table 3 Therapies instituted with infliximab 10 mg/kg

Answer options	Percentage (n)
Corticosteroids	70.5 (55)
Aminosalicylates	61.5 (48)
Azathioprine1	39.7 (31)
6-mercaptopurine1	34.6 (27)
Antibiotics	44.9 (35)
None	11.5 (9)
Methotrexate	6.7 (5)
Other	1.3 (1)

¹Reported use by physicians included either azathioprine or 6-mercaptopurine for different patients. 78 respondents.

Table 4 Outcomes reported using infliximab 10 mg/kg

Answer options	Percentage (n)
Maintenance of remission	80.8 (63)
Clinical remission	78.2 (61)
Colectomy	60.3 (47)
Continued or worsening colitis	51.3 (40)
Other	2.6 (2)
Mortality	1.3 (1)

78 respondents.

Table 5 Side effects and adverse reactions

Answer options	Percentage (n)
None	64.1 (50)
Antibodies to infliximab	17.9 (14)
Infusion reaction or delayed hypersensitivity reaction	16.7 (13)
Worsening ulcerative colitis	14.1 (11)
Infection	12.8 (10)
Headache	9.0 (7)
Arthralgia	9.0 (7)
Development of autoimmune antibodies (e.g., antinuclear antibodies, anti-dsDNA antibodies)	5.1 (4)
Other	2.6 (2)
Profound anemia	1.3 (1)
Oncologic process	0 (0)
Neurologic event (e.g., neuritis, neuropathy)	0 (0)

78 respondents.