Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma

Table 1 Correlation of transcriptional intermediary factor 1 gamma overexpression, Smad4 inactivation, and transforming growth factor-beta receptor type II overexpression with various clinicopathological features (%)

	n	TIF1γoverexpression	Smad4loss	TGFβRIIoverexpression
Stage
I + II	30	10 (33.3)	11 (36.6)	15 (50.0)
III	21	14 (66.7)a	11 (52.4)	14 (66.6)
Grades of differentiation
Well-mod	37	18 (48.6)	18 (48.6)	27 (73.0)
Poor	8	4 (50.0)	2 (25.0)	2 (25.0)
Mucinous	6	2 (33.3)	2 (33.3)	0 (0.0)
Site
Right	27	10 (37.0)	10 (37.0)	13 (48.2)
Left	16	10 (62.5)	7 (43.8)	10 (62.5)
Rectal	8	4 (50.0)	5 (62.5)	6 (75.0)
Kras mutation
Present	11	6 (54.5)	9 (81.8)a	8 (72.7)
Absent	26	10 (38.5)	11 (42.3)	14 (53.8)

^aP < 0.05. TIF1γ: Transcriptional intermediary factor 1 gamma; TGFβRII: Transforming growth factor-beta receptor type II.