Association between ITGA2 C807T polymorphism and gastric cancer risk

Table 1 Demographic information n (%)

Characteristics	Cases (n = 307)	Controls (n = 307)	P value
Gender (male)	231 (75.2)	231 (75.2)	1.000
Age1 (yr), (range)	59 (50-68)	58 (49-66)	0.145
Weight1 (kg), (range)	62 (55-70)	65 (57-72.75)	0.001
Hypertension	65 (21.17)	59 (19.22)	0.546
Diabetes	17 (5.54)	24 (7.82)	0.262
Smoking	82 (26.71)	53 (17.26)	0.005
Residence
Rural	139 (45.28)	139 (45.28)	1.000
Urban	168 (54.72)	168 (54.72)

¹Median (25th-75th percentiles).

Table 2 Distributions of ITGA2 genotype in cases and controls and risk estimates n (%)

ITGA2 genotype	Cases1	Controls1	Crude OR (95% CI)	P value	Adjusted OR2 (95% CI)	P value
Overall	307	307
CC	141 (45.93)	170 (55.37)	1.00		1.00
CT	135 (43.97)	113 (36.81)	1.44 (1.03-2.01)	0.033	1.54 (1.10-2.18)	0.013
TT	31 (10.10)	24 (7.82)	1.56 (0.87-2.78)	0.133	1.62 (0.90-2.91)	0.112
CT + TT	166 (54.07)	137 (44.63)	1.46 (1.06-2.01)	0.019	1.57 (1.13-2.17)	0.007
C allele	417 (67.92)	453 (73.78)
T allele	197 (32.08)	161 (26.22)

¹Distributions of the ITGA2 genotype in cases and controls were in Hardy-Weinberg equilibrium (P = 0.988, P = 0.675, respectively);

²Adjusted for age, sex, smoking status, residence, hypertension and diabetes. OR: Odds ratio.

Table 3 Stratified analyses for variant ITGA2 genotypes in cases and controls n (%)

Variable	(CT + TT)/CC		Crude OR (95% CI)	P value	Adjusted OR1 (95% CI)	P value
	Cases	Controls
Age (yr), (median)
≤ 58	81 (26.4)/68 (22.1)	80 (26)/85 (27.7)	1.27 (0.81-1.97)	0.298	1.31 (0.83-2.06)	0.247
> 58	85 (27.7)/73 (23.8)	57 (18.6)/85 (27.7)	1.74 (1.10-2.75)	0.018	1.88 (1.17-3.03)	0.010
Sex
Females	45 (14.7)/31 (10.1)	38 (12.4)/38 (12.4)	1.45 (0.76-2.76)	0.255	1.52 (0.73-2.93)	0.206
Males	110 (35.8)/121 (39.4)	99 (32.2)/132 (43)	1.21 (0.85-1.73)	0.304	1.29 (0.82-2.01)	0.287
Smoking status
Smokers	40 (13)/42 (13.7)	19 (6.2)/34 (11.1)	1.70 (0.84-3.46)	0.141	1.87 (0.89-3.94)	0.100
Non-smokers	126 (41)/99 (32.3)	118 (38.4)/136 (44.3)	1.47 (1.02-2.10)	0.037	1.51 (1.05-2.18)	0.028
Residence
Urban	89 (29)/79 (25.7)	84 (27.4)/84 (27.4)	1.13 (0.73-1.73)	0.585	1.17 (0.76-1.81)	0.479
Rural	77 (25.1)/62 (20.2)	53 (17.2)/86 (28)	2.02 (1.25-3.25)	0.004	2.35 (1.42-3.90)	0.001

¹Adjusted for age, sex, smoking status, residence, hypertension, and diabetes. OR: Odds ratio.

Table 4 Associations between variant ITGA2 genotypes and clinicopathological characteristics of gastric cancer¹

Variable	CT + TT	CC	Crude OR (95% CI)	P value	Adjusted OR2 (95% CI)	P value
Tumor differentiation
Well	42	42	1		1
Moderate	65	69	0.94 (0.55-1.63)	0.830	0.94 (0.54-1.63)	0.828
Poor	55	27	2.04 (1.09-3.82)	0.027	2.21 (1.12-4.38)	0.022
Depth of tumor infiltration
T1	24	30	1		1
T2	21	17	1.54 (0.67-3.56)	0.308	1.76 (0.73-4.25)	0.208
T3	34	40	1.06 (0.53-2.15)	0.866	1.10 (0.52-2.32)	0.797
T4	83	51	2.03 (1.07-3.86)	0.030	2.12 (1.10-4.07)	0.024
Lymph node metastasis
Negative	59	51	1		1
Positive	103	87	1.02 (0.64-1.64)	0.923	0.98 (0.61-1.58)	0.942
Localization
Cardia	38	41	1		1
Non-cardia	128	100	1.38 (0.83-2.31)	0.217	1.38 (0.81-2.35)	0.231

¹Data of seven plaintively treated cases were not obtained for the inoperable tumors;

²Adjusted for age, sex, smoking status, residence, hypertension, and diabetes. OR: Odds ratio.