Treatment of pediatric refractory Crohn’s disease with thalidomide

Table 1 Parameters of patients, doses of thalidomide and pediatric Crohn’s disease activity index scores

	Patients
	A	B	C	D	E	F
Gender	M	M	M	F	M	F
Current age	20	13	12	16	9	13
Age at onset (yr)	12	10	11	11	5	11
Duration of disease (yr)	8	3	1	5	4	2
Thalidomide start age (yr)	16	12	12	16	9	13
Duration of thalidomide treatment (mo)	12	14	10	10	7	7
Start dose (mg/kg per day)	2	2	2	2	2	2
Dose at sixth months (mg/kg per day)	1	0.2	0.5	0.3	1	1
PCDAI score before thalidomide treatment	55	67.5	70	65	72.5	65
PCDAI score after six months of thalidomide treatment	5	5	7.5	5	5	12.5

PCDAI: pediatric Crohn’s disease activity index.