Omeprazole induces gastric transmucosal permeability to the peptide bradykinin

Table 1 Percent increase in flux of ¹⁴C-EDTA (10 μmol/L) after the addition of 200 μmol/L omeprazole

	Flux value (ρmole/min per cm2)				% increase in flux
	Pre-DMSO	Post-DMSO	Pre-omeprazole	Post-omeprazole	After DMSO	After omeprazole
Experiment 1	1.78	2.03	1.52	3.18	14.0	109.0
Experiment 2	1.65	2.36	1.58	3.48	43.0	120.0
Experiment 3	1.50	2.28	1.69	4.03	52.0	138.0
mean ± SE	1.64 ± 0.08	2.22 ± 0.10	1.60 ± 0.05	3.56 ± 0.25	36.3 ± 11.5	122.3 ± 8.5

Table 2 Percent increase in flux of ³H-bradykinin (0.3 mmol/L) after the addition of 200 μmol/L omeprazole

	Flux value (ρmole/min per cm2)				% increase in flux
	Pre-DMSO	Post-DMSO	Pre-omeprazole	Post-omeprazole	After DMSO	After omeprazole
Experiment 1	10.2	10.4	12.4	21.2	2.0	71.0
Experiment 2	5.0	6.3	5.0	12.4	26.0	148.0
mean ± range	7.6 ± 2.6	8.35 ± 2.1	8.7 ± 3.7	16.8 ± 4.4	14.0 ± 12.0	109.5 ± 38.5

Table 3 Percent change in flux of ³H-oxytocin (5 μmol/L) after the addition of 200 μmol/L omeprazole

	Flux value (fmole/min per cm2)				% increase in flux
	Pre-DMSO	Post-DMSO	Pre-omeprazole	Post-omeprazole	After DMSO	After omeprazole
Experiment 1	20.9	32.3	38.7	45.0	54.5	16.3
Experiment 2	51.5	35.7	31.3	30.2	-30.7	-3.5
mean ± range	36.2 ± 15.3	34.0 ± 1.7	35.0 ± 3.7	37.6 ± 7.4	11.9 ± 42.6	6.4 ± 9.9