Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

Table 1 pH values as 90 mL of the test solution was added to 100 mL of artificial gastric juices

Drug	pH value
Water	1.44 ± 0.03
SJZT	1.57 ± 0.04a
SLBZS	1.76 ± 0.03b
CAP	2.16 ± 0.03b
SB	1.83 ± 0.03b

Data are presented as mean ± SD (n = 6).

^aP < 0.05,

^bP < 0.01 vs water group. SJZT: Si-Jun-Zi-Tang; SLBZS: Shen-Ling-Bai-Zhu-San; CAP: Colloidal aluminum phosphate; SB: Sodium bicarbonate.

Table 2 Duration of antacid effect for consistent neutralization of gastric acids

Drug	Time (min)
Water	87 ± 6
SJZT	123 ± 24
SLBZS	127 ± 5a
CAP	172 ± 3b
SB	121 ± 14

Data are presented as mean ± SD (n = 6).

^aP < 0.05,

^bP < 0.01 vs water group. SJZT: Si-Jun-Zi-Tang; SLBZS: Shen-Ling-Bai-Zhu-San; CAP: Colloidal aluminum phosphate; SB: Sodium bicarbonate.

Table 3 Consumed volume of artificial gastric juice and hydrogen ion (mmol) in the titration of 90 mL test samples with pH 1.2 artificial gastric juice to the end point of pH 3

Drug	Consumed volume of artificial gastric juice (mL)	mmol of H+
Water	1.2 ± 0.17	0.08 ± 0.01
SJZT	22.4 ± 1.10b	1.41 ± 0.07b
SLBZS	33.3 ± 0.85b	2.10 ± 0.05b
CAP	58.9 ± 0.79b	3.72 ± 0.05b
SB	69.2 ± 0.96b	4.37 ± 0.06b

Data are presented as mean ± SD (n = 6).

^bP < 0.01 vs water group. SJZT: Si-Jun-Zi-Tang; SLBZS: Shen-Ling-Bai-Zhu-San; CAP: Colloidal aluminum phosphate; SB: Sodium bicarbonate.