Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis

Table 1 Prevalence of different types of CagA tyrosine phosphorylation motifs compared with data obtained from Argent et al[39] and Colombian strains reports in GenBank n (%)

	Type(s) of EPIYA motif
	BC	AABC	ABC	ABCC	ABCCC	AABCC	ABABC	AC	D	Total
Gastritis	1	0	10	6	0	1	0	1	0	19
Atrophic gastritis	0	0	15	5	0	0	1	0	0	21
Intestinal metaplasia	0	1	16	9	0	0	0	0	0	26
Duodenal ulcer	0	0	14	8	0	0	0	0	0	22
Gastric cancer	0	1	11	5	1	0	0	0	0	18
This study total	1 (0.9)	2 (1.9)	66 (62.3)	33 (31.1)	1 (0.9)	1 (0.9)	1 (0.9)	1 (0.9)	0 (0.0)	106
Colombian1	2 (2.2)	2 (2.2)	49 (53.3)	29 (31.5)	1 (1.1)	2 (2.2)	1 (1.1)	1 (1.1)	0 (0.0)	87
Argent et al[39]2	3 (0.7)	3 (0.7)	262 (63.3)	81 (19.6)	19 (4.6)	1 (0.2)	1 (0.2)	4 (1.0)	3	374

¹CagA sequences of Colombian strains recovered on GenBank; ²Data for Western CagA EPIYA types (-A, -B, -C);

³The EPIYA –D was not included in the analysis of this table because it was absent in the Colombian strains. EPIYA: Glutamine acid-Proline-Isoleucine-Tyrosine-Alanine.

Table 2 Association between cagA Glutamine acid-Proline-Isoleucine-Tyrosine-Alanine-C motif number and gastric pathology n (%)

Pathology	No more than 1 EPIYA-C motif	At least 2 or more EPIYA-C motif	OR	95% CI
Gastritis	12 (16.9)	7 (20)	1.000	-
Atrophic gastritis	16 (22.5)	5 (14.2)	1.867	0.47-7.34
Intestinal metaplasia	17 (23.9)	9 (25.7)	1.102	0.32-3.78
Duodenal ulcer	14 (19.7)	8 (22.8)	1.021	0.30-4.51
Gastric cancer	12 (16.9)	6 (17.1)	1.167	0.28-3.65
Total	71	35

EPIYA: Glutamine acid-Proline-Isoleucine-Tyrosine-Alanine.