Retrospective analysis of perianal Paget’s disease with underlying anorectal carcinoma

Table 1 General patient information

Patient	Gender	Age (yr)	Disease status	Treatment
1	Male	80	Synchronous	APR
2	Male	29	Synchronous	APR
3	Female	68	Synchronous	APR
4	Male	63	Synchronous	APR
5	Male	53	Synchronous	Excision biopsy of anorectal lesion + radical radiation therapy for both Paget’s disease and anorectal cancer
6	Male	61	Synchronous	APR
7	Male	81	Synchronous	APR
8	Male	70	Metachronous	Radiation therapy; Inguinal node resection and APR for recurrence

APR: Abdominoperineal resection.

Table 2 Clinicopathological factors (mean ± SE) n (%)

Factors	Value
Distance to anal edge of anorectal cancer (cm)	2.69 ± 0.70
Diameter of anorectal cancer (cm)	3.13 ± 1.76
Diameter of PPD (cm)	4.81 ± 2.59
Dental line involving (%)	100
Mucin producing component	8/8 (100)
Mucinous adenocarcinoma	5/8 (62.5)
Signet ring cell cancer	1/8 (12.5)
Mix typed	2/8 (25)
Stages of anorectal cancer
I	5/8 (62.5)
II	2/8 (25)
III	1/8 (12.5)

PPD: Perianal Paget’s disease.

Table 3 Stage and management of PPD

Stage	Description	Management
I	Paget’s cells found in perianal epidermis and adnexae without primary carcinoma	WLE
IIA	Cutaneous Paget’s disease with associated adnexal carcinoma	WLE
IIB	Cutaneous Paget’s disease with associated anorectal carcinoma	APR
III	Paget’s disease in which associated carcinoma has spread to regional nodes	ILND + WLE/APR
IV	Paget’s disease with distant metastases of associated carcinoma	CT + RT + LPM

WLE: Wide local excision; ILND: Inguinal lymph node dissection; CT: Chemotherapy; RT: Radiotherapy; LPM: Local palliative management.