Dual specimens increase the diagnostic accuracy and reduce the reaction duration of rapid urease test

Table 1 Validity of rapid urease tests in the treatment naïve group

Method	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)	P1
Sampling over antrum with reaction time: 30 min
HelicotecUT plus	80.6	96.2	91.5	90.8	91.0
HelicotecUT	77.6	98.5	96.3	90.0	92.0
CLO	84.6	96.2	91.8	92.1	92.0
ProntoDry	83.6	95.5	90.3	92.0	91.5	0.988
Sampling over antrum with reaction time: 24 h
HelicotecUT plus	91.0	94.7	89.7	95.5	93.5
HelicotecUT	85.1	94.7	89.1	92.6	91.5
CLO	92.5	95.5	91.2	96.2	94.5
ProntoDry	92.5	94.7	90.0	96.2	94.0	0.642
Sampling over antrum plus body with reaction time: 30 min
HelicotecUT plus	98.5	92.5	86.8	99.2	94.5
HelicotecUT	95.5	94.7	90.1	97.7	95.0
CLO	97.0	94.0	89.0	98.4	95.0
ProntoDry	97.0	91.7	85.5	98.4	93.5	0.902

¹χ² test of four RUTs accuracy.

RUTs: Rapid urease tests; PPV: Positive predictive value; NPV: Negative predictive value.

Table 2 Validity of rapid urease tests in the eradicated group

Method	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)	P1
Sampling over antrum with reaction time: 30 min
HelicotecUT plus	50.0	100.0	100.0	87.7	89.0
HelicotecUT	44.1	100.0	100.0	86.4	87.7
CLO	55.9	100.0	100.0	89.0	90.3
ProntoDry	50.0	100.0	100.0	87.7	89.0	0.913
Sampling over antrum with reaction time: 24 h
HelicotecUT plus	61.8	100.0	100.0	90.3	91.6
HelicotecUT	58.8	100.0	100.0	90.0	91.0
CLO	64.7	99.2	95.7	91.0	91.6
ProntoDry	64.7	100.0	100.0	91.0	92.3	0.983
Sampling over antrum plus body with reaction time: 30 min
HelicotecUT plus	88.2	99.2	96.8	96.8	96.8
HelicotecUT	82.4	100.0	100.0	95.3	96.1
CLO	88.2	98.3	93.8	96.7	96.1
ProntoDry	82.4	100.0	100.0	95.3	96.1	0.987

¹χ² test of four RUTs accuracy.